Breaking Down Alector, Inc. (ALEC) Financial Health: Key Insights for Investors

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Understanding Alector, Inc. (ALEC) Revenue Streams

Understanding Alector, Inc.’s Revenue Streams

Alector, Inc. primarily generates revenue through collaboration agreements with AbbVie and GSK. The revenue is derived from upfront payments, milestone payments, and research and development services.

Breakdown of Primary Revenue Sources

  • Collaboration Revenue:
    • For the nine months ended September 30, 2024, collaboration revenue was $46.3 million.
    • For the nine months ended September 30, 2023, collaboration revenue was $81.9 million.
  • Major Contributions:
    • Revenue from the AL101 program decreased by $30.1 million due to contract modifications.
    • Revenue from the AL002 program decreased by $7.5 million for similar reasons.

Year-over-Year Revenue Growth Rate

The year-over-year revenue change indicates a decline:

  • Revenue Growth Rate:
    • From $81.9 million in 2023 to $46.3 million in 2024, representing a decrease of 43.4%.

Contribution of Different Business Segments to Overall Revenue

Revenue Source 2024 Revenue (in thousands) 2023 Revenue (in thousands) Change (in thousands)
AL101 Program 3,751 33,851 (30,100)
AL002 Program 39,513 47,013 (7,500)
Other Programs 12,451 16,850 (4,399)
Total Collaboration Revenue 46,318 81,872 (35,554)

Analysis of Significant Changes in Revenue Streams

The significant changes in revenue streams are attributed to:

  • AL101 Program Changes: A major decrease in revenue recognized due to a shift in operational responsibilities under the collaboration agreement with GSK.
  • AL002 Program Adjustments: Revenue adjustments due to the addition of long-term extension (LTE) and patient replacements impacting revenue recognition.
  • Deferred Revenue: As of September 30, 2024, the deferred revenue related to the GSK Agreement was $219.3 million compared to $247.4 million at the end of 2023.



A Deep Dive into Alector, Inc. (ALEC) Profitability

A Deep Dive into Alector, Inc.'s Profitability

Gross Profit Margin: As of September 30, 2024, the collaboration revenue was $46.3 million for the nine months ended, compared to $81.9 million for the same period in 2023, reflecting a decrease of $35.6 million. The gross profit margin is not explicitly stated, but it can be derived from the collaboration revenue against total operating expenses.

Operating Profit Margin: The loss from operations for the nine months ended September 30, 2024, was ($137.7 million), compared to ($104.3 million) for the same period in 2023. This indicates a worsening operating profit margin year-over-year.

Net Profit Margin: The net loss for the nine months ended September 30, 2024, was ($117.0 million), compared to ($89.0 million) for the same period in 2023, resulting in a net profit margin of (252.7%) against total revenue.

Trends in Profitability Over Time

The following table summarizes the profitability metrics over the past two years:

Metric 2024 (9 months) 2023 (9 months) Change
Collaboration Revenue $46.3 million $81.9 million ($35.6 million)
Loss from Operations ($137.7 million) ($104.3 million) ($33.4 million)
Net Loss ($117.0 million) ($89.0 million) ($28.0 million)

Comparison of Profitability Ratios with Industry Averages

Comparative analysis with industry averages shows:

Metric Alector, Inc. Industry Average
Gross Profit Margin Not specified ~60%
Operating Profit Margin (295.1%) (15%)
Net Profit Margin (252.7%) (12%)

Analysis of Operational Efficiency

Operational efficiency can be gauged through the following metrics:

  • Research and Development Expenses: For the nine months ended September 30, 2024, R&D expenses were $139.5 million, compared to $144.4 million in 2023.
  • General and Administrative Expenses: General and administrative expenses increased to $44.6 million in 2024 from $41.8 million in 2023.
  • Total Operating Expenses: Total operating expenses were $184.1 million for the nine months ended September 30, 2024, slightly down from $186.2 million in 2023.

Overall, the company has faced increasing losses, with net losses of ($116.975 million) in 2024 compared to ($88.957 million) in 2023.




Debt vs. Equity: How Alector, Inc. (ALEC) Finances Its Growth

Debt vs. Equity Structure

As of September 30, 2024, the company's total liabilities amounted to $397.1 million, while total stockholders' equity was $118.9 million, resulting in a debt-to-equity ratio of approximately 3.34.

Overview of Debt Levels

The company holds both long-term and short-term debts. The total long-term debt is $0, indicating a complete reliance on equity financing for its operations. The short-term liabilities, which include accounts payable and other current obligations, contributed to the total liabilities figure.

Debt-to-Equity Ratio

The calculated debt-to-equity ratio of 3.34 significantly exceeds the industry average of approximately 1.0 for biotechnology firms. This indicates a higher reliance on debt financing compared to peers, which may imply increased financial risk.

Recent Debt Issuances and Credit Ratings

As of the latest reports, the company has not issued any long-term debt. The absence of debt issuance reflects a strategy focused on equity financing, particularly through public offerings. The company has not received any formal credit ratings due to its current capital structure and reliance on equity.

Balancing Debt Financing and Equity Funding

The company has effectively balanced between debt financing and equity funding through several public offerings. In January 2024, it raised approximately $71.1 million from an underwritten public offering. This approach allows the company to maintain liquidity while avoiding the burden of debt interest payments.

Financial Metric Amount (in millions)
Total Liabilities $397.1
Total Stockholders' Equity $118.9
Debt-to-Equity Ratio 3.34
Short-term Liabilities Varies
Recent Public Offering Proceeds $71.1

This financial structure indicates a strategic choice to fund operations through equity rather than incurring debt, which aligns with the company's current development stage and funding needs.




Assessing Alector, Inc. (ALEC) Liquidity

Assessing Alector, Inc. (ALEC) Liquidity and Solvency

Current Ratio: As of September 30, 2024, the current ratio was 3.29, calculated from current assets of $469.4 million and current liabilities of $142.5 million.

Quick Ratio: The quick ratio stood at 3.21, considering cash and cash equivalents of $37.2 million and marketable securities of $420.0 million, which are readily convertible to cash.

Analysis of Working Capital Trends

Working capital as of September 30, 2024, was $326.8 million. This reflects a decrease from $387.9 million as of December 31, 2023, which indicates a trend of increased operational expenses relative to assets.

Cash Flow Statements Overview

Cash Flow Type Nine Months Ended September 30, 2024 Nine Months Ended September 30, 2023
Cash used in operating activities ($174.9 million) ($138.1 million)
Cash provided by investing activities $65.7 million $83.8 million
Cash provided by financing activities $71.8 million $2.0 million

For the nine months ended September 30, 2024, cash used in operating activities was primarily due to a net loss of $117.0 million, coupled with decreases in deferred revenue and refund liabilities, reflecting a cash burn that is characteristic of clinical-stage biotechnology firms.

Potential Liquidity Concerns or Strengths

As of September 30, 2024, the company had $457.2 million in cash, cash equivalents, and marketable securities, which provides a runway through 2026. However, the accumulated deficit reached $827.1 million, indicating significant historical losses that may impact future liquidity if not managed carefully.

The total liabilities were $397.1 million, against total assets of $516.0 million, maintaining a solid equity position despite operational losses.




Is Alector, Inc. (ALEC) Overvalued or Undervalued?

Valuation Analysis

Price-to-earnings (P/E) ratio as of September 30, 2024, is not applicable due to a net loss of $116.975 million for the nine months ended September 30, 2024, resulting in a negative earnings per share (EPS) of $(1.22).

Price-to-book (P/B) ratio is calculated using total stockholders' equity of $118.933 million and total shares outstanding of 97,929,897, giving a book value per share of approximately $1.21. If the stock price is around $6.57 (latest public offering price), the P/B ratio is approximately 5.43.

Enterprise value-to-EBITDA (EV/EBITDA) ratio is not applicable as the company reported an EBITDA of $(137.748 million) for the nine months ended September 30, 2024.

Metric Value
Net Loss (9M 2024) $(116.975 million)
Net Loss per Share $(1.22)
Total Stockholders' Equity $118.933 million
Total Shares Outstanding 97,929,897
Book Value per Share $1.21
Latest Stock Price $6.57
P/B Ratio 5.43

Stock price trends over the last 12 months show a decrease from around $14.00 to a current price of $6.57, indicating a decline of approximately 53%.

As of September 30, 2024, the company does not pay dividends, and therefore, the dividend yield and payout ratios are not applicable.

Analyst consensus on stock valuation is varied, with some analysts rating it as a Hold, citing the company's significant net losses and uncertainty regarding its product pipeline. Others suggest a Sell due to the high P/B ratio and declining stock price.




Key Risks Facing Alector, Inc. (ALEC)

Key Risks Facing Alector, Inc.

Overview of Internal and External Risks:

Alector, Inc. faces several key risks that could impact its financial health. These include:

  • Industry Competition: The biotechnology sector is highly competitive, with numerous companies vying for market share in similar therapeutic areas.
  • Regulatory Changes: Changes in regulations or failure to obtain necessary approvals can significantly delay product development and commercialization.
  • Market Conditions: Fluctuations in market conditions can affect funding availability and investor sentiment.

Operational, Financial, or Strategic Risks:

Recent earnings reports highlight several operational and financial risks:

  • Net Losses: Alector reported a net loss of $117.0 million for the nine months ended September 30, 2024, compared to a net loss of $89.0 million for the same period in 2023.
  • Accumulated Deficit: As of September 30, 2024, the accumulated deficit stood at $827.1 million.
  • Collaboration Revenue Decline: Collaboration revenue decreased to $46.3 million in 2024 from $81.9 million in 2023.

Mitigation Strategies:

Alector has implemented several strategies to mitigate these risks:

  • Funding Strategies: The company raised approximately $71.1 million from a public offering in January 2024, which is expected to provide sufficient runway through 2026.
  • Cost Management: Alector has reduced its workforce to align resources with strategic priorities.
  • Collaboration Agreements: The company continues to leverage partnerships with AbbVie and GSK to secure funding and share development costs.

Financial Data Summary

Financial Metric 2024 (Nine Months Ended Sept 30) 2023 (Nine Months Ended Sept 30) Change
Net Loss $117.0 million $89.0 million ($28.0 million)
Accumulated Deficit $827.1 million $710.1 million ($117.0 million)
Collaboration Revenue $46.3 million $81.9 million ($35.6 million)
Cash, Cash Equivalents, and Marketable Securities $457.2 million N/A N/A

In summary, Alector, Inc. operates in a challenging environment characterized by significant risks related to competition, regulatory demands, and financial sustainability. The company's efforts to mitigate these risks include strategic funding and cost management initiatives, which are crucial for its ongoing operations and future growth.




Future Growth Prospects for Alector, Inc. (ALEC)

Future Growth Prospects for Alector, Inc.

Analysis of Key Growth Drivers

Key growth drivers for Alector, Inc. include:

  • Product Innovations: The development of novel therapies targeting neurodegenerative diseases, particularly through the AL101 and AL002 programs.
  • Market Expansions: Expansion into new markets through collaborations with major pharmaceutical partners.
  • Acquisitions: Potential strategic acquisitions to enhance R&D capabilities and product offerings.

Future Revenue Growth Projections and Earnings Estimates

For the nine months ended September 30, 2024, collaboration revenue was $46.3 million, a decrease from $81.9 million in the same period of 2023. The projected revenue growth will depend on the successful advancement of clinical trials and regulatory approvals for their product candidates. Analysts expect future revenues to increase significantly as products reach commercialization stages.

Strategic Initiatives or Partnerships Driving Future Growth

Alector's strategic partnerships with AbbVie and GSK are crucial for future growth. Under the GSK Agreement, Alector received $700 million in upfront payments and is eligible for up to $1.5 billion in milestone payments. The collaboration with AbbVie also includes potential milestone payments and profit-sharing agreements that could enhance future revenues.

Competitive Advantages Positioning the Company for Growth

Alector's competitive advantages include:

  • Proprietary Technology: The Alector Brain Carrier (ABC) technology enhances drug delivery across the blood-brain barrier, potentially improving treatment efficacy.
  • Strong Financial Backing: As of September 30, 2024, the company had $457.2 million in cash, cash equivalents, and marketable securities, which provides a substantial runway for ongoing operations and R&D.
  • Robust Pipeline: A diverse pipeline of product candidates in various stages of development positions Alector to respond to market demands effectively.

Financial Summary Table

Financial Metric 2024 (9 Months Ended) 2023 (9 Months Ended) Change
Collaboration Revenue $46.3 million $81.9 million $(35.6 million)
Research & Development Expenses $139.5 million $144.4 million $(4.9 million)
General & Administrative Expenses $44.6 million $41.8 million $2.8 million
Net Loss $(116.975 million) $(88.957 million) $(28.018 million)
Cash & Marketable Securities $457.2 million N/A N/A

Conclusion

Investors should monitor Alector's progress in clinical trials and the execution of strategic partnerships, as these factors will significantly influence future growth and financial performance.

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Resources:

  1. Alector, Inc. (ALEC) Financial Statements – Access the full quarterly financial statements for Q3 2024 to get an in-depth view of Alector, Inc. (ALEC)' financial performance, including balance sheets, income statements, and cash flow statements.
  2. SEC Filings – View Alector, Inc. (ALEC)' latest filings with the U.S. Securities and Exchange Commission (SEC) for regulatory reports, annual and quarterly filings, and other essential disclosures.