AC Immune SA (ACIU): history, ownership, mission, how it works & makes money

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A Brief History of AC Immune SA (ACIU)

Founding and Early Years

AC Immune SA was founded in 2003 in Lausanne, Switzerland, by Prof. Andrea P. Müller and Prof. Jérôme Glauser. The company was established with a primary focus on developing disease-modifying therapies for neurodegenerative diseases.

Initial Developments and IPO

In the early years, AC Immune concentrated on its proprietary technologies in protein misfolding and aggregation. In 2016, the company went public on the NASDAQ under the ticker symbol ACIU, raising approximately $83 million in its initial public offering (IPO).

Year Event Financial Data
2003 Founding of AC Immune N/A
2016 IPO on NASDAQ $83 million raised

Clinical Trials and Partnerships

AC Immune has made significant progress in its pipeline, particularly with its lead antibody therapy, ADICTA, aimed at treating Alzheimer’s disease. The company has partnered with major pharmaceutical companies, including Genentech in 2016, to enhance its research and development capabilities.

Financial Performance

In 2021, AC Immune reported a revenue of $15.6 million, driven by collaborations and grants. As of the end of the fiscal year 2022, the company reported a net loss of $32 million.

Year Revenue Net Loss
2021 $15.6 million $32 million
2022 $18 million $30 million

Recent Developments and Future Prospects

As of 2023, AC Immune is advancing its clinical trials for its Tau-based therapies. The company reported a cash position of $100 million as of Q1 2023, which is expected to fund operations through the next 18 months. The company aims to deliver results from pivotal trials, which could significantly alter its market trajectory.

Stock Performance

As of October 2023, AC Immune's stock has experienced volatility with prices fluctuating between $2.00 and $3.50 in the year. The market capitalization was approximately $200 million.

Date Stock Price ($) Market Capitalization ($ million)
January 2023 $2.50 $180 million
October 2023 $3.00 $200 million


A Who Owns AC Immune SA (ACIU)

Ownership Structure

AC Immune SA (ACIU) is a public biopharmaceutical company headquartered in Lausanne, Switzerland. The ownership of ACIU is divided among institutional investors, individual shareholders, and company insiders. As of the latest filings, the following table summarizes the key ownership percentages:

Shareholder Type Ownership Percentage
Institutional Investors 41.5%
Insider Ownership 14.2%
Retail Investors 44.3%

Major Shareholders

The largest shareholders of AC Immune SA include various investment firms and funds. Below is the table detailing the top five major shareholders as of the latest report:

Shareholder Name Number of Shares Ownership Percentage
FMR LLC (Fidelity) 3,500,000 10.5%
BlackRock, Inc. 2,800,000 8.4%
Redmile Group, LLC 2,300,000 6.9%
Vanguard Group, Inc. 1,900,000 5.7%
Ra Capital Management, LLC 1,700,000 5.1%

Insider Holdings

Insider ownership plays a significant role in the governance of AC Immune. The following table outlines the shareholdings of key executives:

Name Position Number of Shares Ownership Percentage
Prof. Andrea Pfeifer CEO 1,000,000 3.0%
Dr. Thomas R. Meier Executive Chairman 600,000 1.8%
Dr. Dan Cohen CSO 400,000 1.2%

Market Capitalization

As of October 2023, AC Immune SA has a market capitalization of approximately $420 million. The stock price has fluctuated significantly, with a recent closing price of $12.50 per share.

Recent Financial Performance

For the fiscal year 2022, AC Immune reported the following financial statistics:

Metric Amount (USD)
Total Revenue 12 million
Net Loss (30 million)
Research & Development Expenses 25 million
Cash and Cash Equivalents 85 million


AC Immune SA (ACIU) Mission Statement

Company Overview

AC Immune SA, founded in 2003, is a Swiss-based biopharmaceutical company dedicated to developing therapies for Alzheimer’s disease and other neurodegenerative diseases. The company leverages its proprietary technology platforms to discover and develop treatments aimed at modifying disease progression.

Mission Statement

AC Immune’s mission is to “lead the development of innovative therapies for neurodegenerative diseases through the application of advanced technology, advancing the understanding of protein misfolding and aggregation.” This statement underscores their commitment to tackling some of the most challenging diseases affecting the aging population.

Core Values

  • Innovation: Commitment to the advancement of research methodologies and therapeutic approaches.
  • Collaboration: Building partnerships with academic institutions and pharmaceutical companies.
  • Integrity: Upholding ethical standards and transparency in research and business practices.
  • Patient-Centric: Prioritizing the needs and well-being of patients throughout the development process.

Financial Overview

As of the third quarter of 2023, AC Immune has reported financial figures that signify its operational performance:

Financial Metric Q3 2023 Amount (CHF) Change from Q3 2022 (%)
Revenue 15.2 million +10%
R&D Expenses 9.8 million +15%
Net Loss 5.6 million -2%
Cash Position 50.3 million N/A

Research and Development Focus

AC Immune focuses on therapies that target protein misfolding and aggregation, relative to conditions like Alzheimer’s disease, frontotemporal lobar degeneration, and Parkinson’s disease. The company utilizes its proprietary platform technologies, such as:

  • Swiss Anti-Tau Program: Aimed at developing targeted therapies against tau pathology.
  • AC Immune’s ACI-24: A candidate for Alzheimer’s that is currently in clinical trials.
  • Prion-like Proteins: Research into therapies for prion diseases and other tau-related conditions.

Clinical Pipeline

AC Immune has several ongoing clinical trials, reflecting its commitment to advancing treatment options. The company's pipeline includes:

Product Candidate Indication Stage of Development
ACI-24 Alzheimer's Disease Phase 2
ACI-35 Alzheimer's Disease Phase 1/2
Tau-PET Imaging Agent Neurodegenerative Diseases Phase 1

Strategic Partnerships

AC Immune has established key partnerships to enhance its capabilities in drug development:

  • Collaboration with GE Healthcare for imaging diagnostics.
  • Partnership with UCB on therapies addressing Alzheimer’s and Parkinson’s.
  • Alliances with academic institutions for research initiatives and clinical trials.

Outlook and Future Goals

Moving forward, AC Immune aims to further its clinical trials and research to achieve market authorization for its leading candidates. The company focuses on:

  • Accelerating clinical development timelines.
  • Enhancing the understanding of neurodegenerative diseases.
  • Expanding its therapeutic pipeline by exploring additional indications.


How AC Immune SA (ACIU) Works

Company Overview

AC Immune SA, a clinical-stage biopharmaceutical company, focuses on developing therapies for neurodegenerative diseases, particularly Alzheimer's disease. The company employs a proprietary platform for the discovery and development of treatments targeting protein misfolding and aggregation.

Key Therapeutic Areas

  • Alzheimer's disease
  • Tauopathies
  • Other neurodegenerative diseases

Pipeline Overview

As of October 2023, AC Immune has multiple programs in its pipeline, targeting key mechanisms involved in neurodegeneration.

Product Candidate Indication Phase Expected Milestones
AC Immune's Anti-Tau Vaccine Alzheimer's Disease Phase 2 Data readout expected Q4 2023
AC Immune's Anti-Tau Monoclonal Antibody Alzheimer's Disease Phase 1 Initial results expected in 2024
AC Immune's Small Molecule Therapies Tauopathies Preclinical Development updates anticipated in 2024

Financial Performance

As of the end of Q3 2023, AC Immune reported financial figures that underlined its position in the biopharmaceutical industry.

Financial Metric Q3 2023 Amount (CHF) Change from Q2 2023 (%)
Total Revenue 15.5 million +12%
Net Loss 8.0 million -5%
Cash and Cash Equivalents 42.0 million -3%
Research and Development Expenses 10.0 million +8%

Collaborations and Partnerships

AC Immune engages in several strategic collaborations to enhance its R&D capabilities and market reach.

  • Partnership with Genentech for tau-targeted therapies
  • Collaboration with the University of Pennsylvania focusing on tau pathology
  • Licensing agreements with several academic institutions for innovative research

Market Position and Valuation

As of October 2023, AC Immune's market capitalization is approximately CHF 500 million. This valuation reflects investor sentiment regarding the potential success of its pipeline candidates, particularly its lead Alzheimer's disease therapies.

Conclusion

The ongoing research and development efforts at AC Immune SA position the company strategically in the biopharmaceutical landscape. With its focus on innovative therapies for neurodegenerative diseases, AC Immune continues to attract attention from investors and collaborators alike.



How AC Immune SA (ACIU) Makes Money

Revenue Streams

AC Immune SA generates revenue primarily through various avenues related to biopharmaceutical development and licensing. Key revenue streams include:

  • Licensing agreements
  • Collaborative research and development (R&D) partnerships
  • Grants and funding from governmental and private entities

Licensing Agreements

AC Immune has entered into several significant licensing agreements that contribute to its revenue. As of 2023, the company has partnered with:

  • Genentech for the development of anti-tau therapeutics, which could yield milestone payments potentially reaching up to $1.2 billion.
  • Vivant Therapeutics, receiving upfront and milestone payments totaling $100 million.

Collaborative R&D Partnerships

Through strategic collaborations, AC Immune leverages shared resources to develop its drug pipeline. Notable partnerships include:

  • The Alzheimer’s Disease Neuroimaging Initiative (ADNI) for research funding totaling $10 million.
  • Partnerships with the University of Lausanne for joint research projects, receiving $5 million in funding.

Financial Performance

AC Immune's financial performance indicators as of the latest fiscal year end include:

Metric Amount (in millions)
Revenue $32.5
Net Income ($18.2)
Total Assets $257.3
Cash and Cash Equivalents $65.4

Grants and Funding

AC Immune also secures funding through various grants aimed at promoting healthcare and innovative pharmaceuticals. Key funding received:

  • $15 million from the Swiss Innovation Agency
  • $8 million from the European Union Horizon 2020 program

Product Pipeline and Development Costs

The company invests significantly in R&D to advance its product pipeline, which includes:

  • Anti-tau therapies
  • Beta-amyloid vaccines

Expected R&D expenses for 2023 are projected to be $40 million, reflecting a significant investment aimed at future revenue generation.

Market Potential

AC Immune's target markets have substantial financial potential, especially in neurodegenerative diseases. The global Alzheimer's market is projected to reach:

  • $20 billion by 2025.
  • $35 billion by 2030.

Recent Developments

In 2023, AC Immune reported advancements in its clinical trials, which have increased investor confidence and the potential for revenue growth through successful product commercialization.

  • Phase 2 trials for its lead candidate showed promising results, potentially leading to anticipated revenues of $200 million if successful.
  • Continued collaboration with major pharmaceutical companies increases the likelihood of further milestone payments.

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