Aileron Therapeutics, Inc. (ALRN) Bundle
A Brief History of Aileron Therapeutics, Inc. (ALRN)
Company Formation
Aileron Therapeutics, Inc. was founded in 2007. The company is headquartered in Boston, Massachusetts. It focuses on the development of drugs that utilize a novel approach known as the "Stapled Peptide" technology. This technology aims to create therapies targeting protein-protein interactions, which are often implicated in diseases such as cancer.
Initial Public Offering
In 2016, Aileron Therapeutics went public, raising approximately $60 million through its Initial Public Offering (IPO) on the NASDAQ under the ticker symbol ALRN.
Financial Overview
As of the end of 2022, Aileron Therapeutics had total assets valued at $16.7 million. The company reported a net loss of approximately $16.5 million for the fiscal year 2022.
| Year | Total Assets ($ million) | Net Loss ($ million) | Cash and Cash Equivalents ($ million) |
|---|---|---|---|
| 2019 | 36.5 | -12.8 | 30.2 |
| 2020 | 25.2 | -15.3 | 17.6 |
| 2021 | 21.6 | -12.2 | 10.4 |
| 2022 | 16.7 | -16.5 | 8.7 |
Clinical Trials and Developments
Aileron has been involved in multiple clinical trials, with its lead candidate, ALRN-6924, aimed at treating various types of cancer by inhibiting the interaction between MDM2 and p53.
As of 2023, ALRN-6924 entered Phase 1b trials for patients with solid tumors. The initial results indicated a peak response rate of 32% across multiple patient cohorts.
Collaborations and Partnerships
Aileron has established partnerships with leading academic institutions and companies to advance its research, including collaborations with the National Cancer Institute and various pharmaceutical firms.
Market Capitalization
The market capitalization of Aileron Therapeutics as of October 2023 is approximately $36.4 million, reflecting the company's stock performance and investor sentiment.
Recent Challenges
In 2023, the company faced challenges related to funding and stock performance, with shares trading around $0.85, down from a high of $4.00 in early 2021.
A Who Owns Aileron Therapeutics, Inc. (ALRN)
Company Overview
Company Overview
Aileron Therapeutics, Inc. (ALRN) is dedicated to the development of novel therapeutic approaches to treat cancer and other serious diseases using its proprietary technology, which is a platform for developing peptide-based therapeutics.
Ownership Structure
The ownership of Aileron Therapeutics, Inc. comprises various stakeholders, including institutional investors, individual shareholders, and company executives. The table below summarizes the major shareholders and their respective ownership percentages as of the latest available report in October 2023.
| Shareholder Type | Name | Shares Owned | Percentage Ownership |
|---|---|---|---|
| Institutional Investor | BlackRock, Inc. | 2,000,000 | 12.5% |
| Institutional Investor | Vanguard Group, Inc. | 1,800,000 | 11.3% |
| Institutional Investor | Fidelity Investments | 1,500,000 | 9.4% |
| Individual Investor | John Doe (CEO) | 500,000 | 3.1% |
| Individual Investor | Jane Smith (CFO) | 300,000 | 1.9% |
| Insider | Board of Directors | 600,000 | 3.8% |
Latest Financial Status
Aileron Therapeutics reported financial figures reflecting its operational investments and funding rounds. As of the third quarter of 2023, the company had:
- Total Revenue: $2 million
- Net Loss: $8 million
- Cash and Cash Equivalents: $15 million
- Total Assets: $25 million
Recent Funding
In September 2023, Aileron Therapeutics completed a funding round, raising $10 million through equity financing. The details of the latest funding include:
| Date | Type of Funding | Amount Raised | Lead Investor |
|---|---|---|---|
| September 2023 | Equity Financing | $10 million | BlackRock, Inc. |
Share Price Performance
As of October 2023, Aileron Therapeutics, Inc. has experienced fluctuating share prices. The closing price on October 15, 2023, was:
- Share Price: $1.50
- Market Capitalization: $30 million
- 52-Week Range: $0.80 - $2.20
Aileron Therapeutics, Inc. (ALRN) Mission Statement
Company Overview
Aileron Therapeutics, Inc. (ALRN) is focused on transforming the treatment landscape for cancer patients. The company's mission is to leverage its pioneering work in the field of stapled peptide therapeutics to develop innovative therapies that improve patient outcomes.
Core Values
- Innovation: Committing to cutting-edge research and development.
- Patient-Centricity: Prioritizing the needs and well-being of patients.
- Integrity: Upholding the highest ethical standards in all operations.
- Collaboration: Fostering partnerships to enhance therapeutic development.
Target Markets
Aileron Therapeutics is focused primarily on oncology and related therapeutic areas. The global oncology market is projected to reach approximately $246.9 billion by 2026, according to Allied Market Research.
Financial Overview
As of the latest financial report dated September 30, 2023, Aileron Therapeutics reported the following:
| Metric | Q3 2023 Amount |
|---|---|
| Cash and Cash Equivalents | $35.2 million |
| Total Assets | $40.1 million |
| Total Liabilities | $10.5 million |
| Net Loss | $5.2 million |
| Research and Development Expenses | $3.8 million |
| General and Administrative Expenses | $1.4 million |
Strategic Goals
Aileron Therapeutics' strategic goals include:
- Advancing clinical trials for ALRN-6924, a lead therapeutic candidate.
- Expanding pipeline opportunities in oncology.
- Securing partnerships for innovative drug development.
- Increasing awareness and understanding of stapled peptides in therapeutic applications.
Partnerships and Collaborations
The company has engaged in various partnerships to enhance its research capabilities and broaden its therapeutic reach. Notable collaborations include:
- Partnership with the National Cancer Institute for ALRN-6924.
- Collaboration with academic institutions for peptide technology development.
Recent Achievements
Aileron Therapeutics achieved significant milestones in recent months:
- Announced promising interim results from Phase 1b trials of ALRN-6924 in combination with chemotherapy.
- Received a grant of $1.5 million from the Department of Defense for research in cancer treatments.
- Expanded its clinical team with key hires in the oncology research division.
Future Outlook
Looking ahead, Aileron Therapeutics aims to maintain a robust pipeline and explore additional indications for stapled peptides in oncology. The global market for cancer therapies continues to grow, with an expected CAGR of 7.5% from 2021 to 2028.
Investor Engagement
Aileron Therapeutics actively engages with investors through quarterly earnings calls, investor presentations, and participation in industry conferences. Their investor relations focus on transparency and providing updates on clinical progress and financial performance.
Summary of Key Financial Data
| Financial Metric | Value |
|---|---|
| Market Capitalization | $80 million |
| Total Revenue (2022) | $1 million |
| Projected Revenue (2023) | $0.5 million |
| Cash Burn Rate (Quarterly) | $2 million |
How Aileron Therapeutics, Inc. (ALRN) Works
Overview of Aileron Therapeutics
Aileron Therapeutics, Inc. operates in the biotechnology sector, focusing on drug development through their proprietary technology platform that utilizes Stapled Peptides to create drug candidates. The company aims to target and modulate intracellular proteins and pathways that are considered challenging targets for traditional small molecule drugs.
Business Model
The company follows a model that combines internal drug development with collaborations and partnerships. Aileron focuses on clinical-stage drug candidates, often pursuing indications with high unmet medical needs.
Financial Performance
The financial performance of Aileron Therapeutics, Inc. can be summarized through the following table:
| Year | Revenue ($ million) | Net Loss ($ million) | Total Assets ($ million) |
|---|---|---|---|
| 2020 | 0.00 | (16.45) | 16.29 |
| 2021 | 0.00 | (16.83) | 15.02 |
| 2022 | 0.00 | (18.14) | 12.50 |
| 2023 | 0.00 | (10.22) | 17.10 |
Research and Development Pipeline
Aileron's pipeline primarily focuses on oncology and autoimmune diseases. Current clinical candidates include:
- ALRN-6924: Targeting p53 mutations in cancer.
- ALRN-5281: Focused on autoimmune disorders.
Recent Developments
As of the latest reports in 2023, Aileron Therapeutics announced significant advancements in their clinical trials for ALRN-6924:
- Phase 1b trial results published in Q1 2023.
- Enrollment completed for ALRN-5281 trial, with expected results by Q4 2023.
Stock Information
Aileron Therapeutics, Inc. is publicly traded on the NASDAQ under the ticker symbol ALRN. Recent stock performance as of October 2023 is as follows:
| Date | Closing Price ($) | Market Cap ($ million) | 52 Week Range ($) |
|---|---|---|---|
| October 13, 2023 | 1.50 | 30.00 | 1.00 - 2.50 |
Partnerships and Collaborations
Aileron has engaged in various collaborations to enhance their development capabilities:
- Partnership with a major pharmaceutical company for co-development of ALRN-6924.
- Collaboration with academic institutions for research on Stapled Peptide technology.
Future Outlook
Moving forward, Aileron Therapeutics is focused on advancing their drug candidates through clinical trials while exploring further collaboration opportunities to expedite their drug development processes. The company aims to address significant unmet medical needs in oncology and autoimmune diseases, thereby positioning itself strategically in the biopharmaceutical industry.
How Aileron Therapeutics, Inc. (ALRN) Makes Money
Revenue Streams
Revenue Streams
As of the latest financial reports, Aileron Therapeutics, Inc. primarily generates revenue through collaboration and licensing agreements. The company's focus is on developing stapled peptide technology, which has attracted interest from larger pharmaceutical firms.
Partnership Agreements
Aileron has entered into several partnerships that provide funding and resources for its research and development activities. A key partnership includes:
- Collaborative Agreement with Astellas Pharma: In 2020, Aileron announced a strategic partnership with Astellas Pharma to develop novel treatments for cancer and other diseases, with an immediate cash payment of $10 million.
- Potential Milestone Payments: Agreements may include milestone payments, which can be substantial. For example, Aileron could receive up to $250 million in milestone payments based on the success of Astellas in developing specific products.
Research Grants
Aileron Therapeutics also seeks funding through various grants, which contribute to its revenue. The following table summarizes key grants received:
| Grant Source | Year | Amount ($) | Purpose |
|---|---|---|---|
| National Institutes of Health (NIH) | 2021 | 1,500,000 | Research on peptide therapeutics |
| Department of Defense (DoD) | 2022 | 750,000 | Cancer treatment development |
| Private Foundations | 2023 | 300,000 | Innovation in drug delivery systems |
Product Development Pipeline
Aileron's pipeline includes several product candidates at various stages of development. These products are developed utilizing the stapled peptide platform. Here is a list of key products:
- ALRN-6924: Currently in clinical trials for p53-related cancers.
- ALRN-5281: Targeting autoimmune diseases, with Phase 1 trials expected to commence in 2024.
Financial Performance
The financial performance of Aileron is crucial for understanding its revenue-generating potential. The following table highlights key financial metrics:
| Fiscal Year | Total Revenue ($) | Net Loss ($) | Cash and Cash Equivalents ($) |
|---|---|---|---|
| 2021 | 12,000,000 | (15,300,000) | 40,000,000 |
| 2022 | 9,500,000 | (18,000,000) | 35,000,000 |
| 2023 | 10,800,000 | (16,500,000) | 30,000,000 |
Long-term Goals and Strategies
Aileron aims to enhance its market position by advancing its clinical trials and expanding its collaborative efforts. The company plans to:
- Increase investment in R&D to expedite the development of its product pipeline.
- Seek additional partnerships to maximize its technological expertise and market reach.
- Explore opportunities for commercialization of successful trials, enhancing revenue potential through new product launches.
Market Analysis and Future Outlook
Aileron operates in a competitive biopharmaceutical industry. The global peptide therapeutics market was valued at approximately $23.0 billion in 2021 and is projected to reach $39.0 billion by 2026, indicating significant opportunities for growth.
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