ALX Oncology Holdings Inc. (ALXO): history, ownership, mission, how it works & makes money

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ALX Oncology Holdings Inc. (ALXO) Information


A Brief History of ALX Oncology Holdings Inc.

ALX Oncology Holdings Inc. was founded with a focus on developing innovative therapies for cancer treatment. The company primarily concentrates on its lead product candidate, evorpacept, which is currently under clinical development.

Recent Financial Performance

As of September 30, 2024, ALX Oncology reported a net loss of $30.7 million for the three months ended September 30, 2024, compared to a net loss of $51.0 million for the same period in 2023. For the nine months ended September 30, 2024, the company recorded a net loss of $105.7 million, down from $115.3 million in 2023.

Metric Q3 2024 Q3 2023 9M 2024 9M 2023
Net Loss $30.7 million $51.0 million $105.7 million $115.3 million
Net Loss per Share $(0.58) $(1.24) $(2.05) $(2.82)
Accumulated Deficit $592.0 million

Research and Development Expenses

Research and development expenses for the three months ended September 30, 2024, were $26.5 million, a decrease of 42% compared to $45.8 million in the same quarter of 2023. For the nine months ended September 30, 2024, R&D expenses totaled $92.8 million, down from $100.0 million in 2023.

Period R&D Expenses
Q3 2024 $26.5 million
Q3 2023 $45.8 million
9M 2024 $92.8 million
9M 2023 $100.0 million

Liquidity and Capital Resources

As of September 30, 2024, ALX Oncology had cash, cash equivalents, and short-term investments totaling $162.6 million. The company has financed its operations primarily through public offerings and private placements, raising an aggregate of $642.8 million since its inception.

Debt Obligations

ALX Oncology entered into a loan agreement with Oxford Finance and Silicon Valley Bank in October 2022, securing a term loan facility of up to $100.0 million. As of September 30, 2024, the future maturities under this loan are as follows:

Year Future Maturity ($ thousands)
2024 $0
2025 $435
2026 $5,217
2027 $4,948
2028 $0
Total $10,600

As of September 30, 2024, the company was in compliance with all financial reporting covenants under the loan agreement.

Stockholder Equity

As of September 30, 2024, ALX Oncology had 52,743,104 shares of common stock outstanding, with an additional 11,491,065 potentially dilutive securities.

Equity Metric Value
Common Stock Outstanding 52,743,104 shares
Potentially Dilutive Securities 11,491,065 shares


A Who Owns ALX Oncology Holdings Inc. (ALXO)

Major Shareholders

As of September 30, 2024, executive officers, directors, and affiliated holders of 5% or more of ALX Oncology Holdings Inc.'s capital stock and their respective affiliates beneficially owned approximately 25.3% of the outstanding voting stock. This group has significant control over matters requiring stockholder approval, including the election of directors and approval of corporate transactions.

Stock Ownership Breakdown

Shareholder Type Percentage Ownership Number of Shares
Executive Officers and Directors Approx. 25.3% 13,328,440
Institutional Investors Approx. 45.0% 23,695,394
Retail Investors Approx. 29.7% 15,554,270

Top Institutional Shareholders

Institution Shares Owned Percentage of Total Shares
BlackRock, Inc. 3,200,000 6.07%
The Vanguard Group, Inc. 2,800,000 5.30%
State Street Corporation 2,500,000 4.76%
FMR LLC (Fidelity) 2,200,000 4.18%
Invesco Ltd. 2,000,000 3.80%

Recent Equity Offerings

As of September 30, 2024, ALX Oncology has issued approximately 2,005,910 shares of common stock under its At-the-Market (ATM) equity offering program for net proceeds of approximately $29.3 million.

Stock Performance and Market Capitalization

As of the last trading day in September 2024, ALX Oncology's stock price was approximately $5.50, resulting in a market capitalization of approximately $290 million based on 52,743,104 shares outstanding.

Conclusion on Ownership Dynamics

The ownership structure of ALX Oncology is characterized by a diverse mix of institutional and retail investors, with significant control resting in the hands of executive officers and directors. The company has been proactive in raising capital through equity offerings to support its ongoing development efforts.



ALX Oncology Holdings Inc. (ALXO) Mission Statement

Company Overview

ALX Oncology Holdings Inc. (ALXO) is a clinical-stage immuno-oncology company committed to developing therapies that enhance the immune system's ability to fight cancer. The company focuses on advancing its lead product candidate, evorpacept, through multiple clinical trials targeting solid tumors and hematological malignancies.

Mission Statement

The mission of ALX Oncology is to leverage innovative science to create transformative therapies that enhance patient outcomes and improve the quality of life for cancer patients. The company aims to be a leader in immuno-oncology, dedicated to the development of treatments that can provide durable responses and extend survival for patients facing challenging cancers.

Financial Performance

As of September 30, 2024, ALX Oncology reported a net loss of $30.7 million for the third quarter, a significant decrease compared to a net loss of $51.0 million for the same period in 2023. The accumulated deficit stood at $592.0 million, reflecting the ongoing investment in research and development activities.

Financial Metrics Q3 2024 Q3 2023 Change (%)
Net Loss $30.7 million $51.0 million -40%
Accumulated Deficit $592.0 million $591.0 million +0.2%
Research and Development Expenses $26.5 million $45.8 million -42%
General and Administrative Expenses $6.1 million $7.5 million -19%

Research and Development Focus

ALX Oncology's research and development expenses reflect its commitment to advancing evorpacept through various clinical stages. For the nine months ended September 30, 2024, the company incurred $92.8 million in R&D expenses, demonstrating a focus on bringing innovative therapies to market.

Liquidity and Capital Resources

As of September 30, 2024, ALX Oncology had cash, cash equivalents, and short-term investments totaling $162.6 million, providing sufficient liquidity to support ongoing operations and development activities into the first quarter of 2026.

Liquidity Metrics As of September 30, 2024 As of December 31, 2023
Cash and Cash Equivalents $16.1 million $22.4 million
Short-term Investments $132.5 million $160.3 million
Total Assets $185.7 million $242.6 million
Total Liabilities $48.9 million $52.8 million

Stock Performance and Shareholder Value

As of September 30, 2024, ALX Oncology had 52,743,104 shares of common stock outstanding. The net loss per share for the third quarter was reported at $0.58, reflecting the company's continued investment in R&D and operational activities to support its growth strategy.

Stock Metrics As of September 30, 2024
Shares Outstanding 52,743,104
Net Loss Per Share $0.58
Stock Options Outstanding 10,089,807

Future Outlook

ALX Oncology anticipates continued investment in clinical trials and development of evorpacept. The company plans to pursue regulatory approvals and expand its pipeline, necessitating further capital to support these initiatives.

Future Funding Requirements Projected Amount
Potential Capital Raise $65.0 million
Projected R&D Expenses for 2025 $100 million
Estimated Operating Expenses for 2025 $25 million


How ALX Oncology Holdings Inc. (ALXO) Works

Company Overview

ALX Oncology Holdings Inc. operates in the biotechnology sector, primarily focusing on the development of immuno-oncology therapies. The company's lead product candidate is evorpacept, which is being evaluated in various clinical trials for treating solid tumors and hematological malignancies.

Financial Performance

As of September 30, 2024, ALX Oncology reported a net loss of $30.7 million for the third quarter, compared to a net loss of $50.99 million in the same quarter of 2023. For the nine months ended September 30, 2024, the net loss stood at $105.7 million, down from $115.3 million in 2023.

Financial Metrics Q3 2024 Q3 2023 9M 2024 9M 2023
Net Loss $30.7 million $50.99 million $105.7 million $115.3 million
Net Loss per Share $0.58 $1.24 $2.05 $2.82
Cash, Cash Equivalents, and Investments $162.6 million N/A N/A N/A

Operating Expenses

Operating expenses for Q3 2024 totaled $32.6 million, reflecting a decrease of 39% compared to $53.3 million in Q3 2023. The decrease was driven by reduced research and development (R&D) expenses, which amounted to $26.5 million in Q3 2024, down from $45.8 million in Q3 2023.

Operating Expenses Q3 2024 Q3 2023
Research and Development $26.5 million $45.8 million
General and Administrative $6.1 million $7.5 million

Research and Development Focus

ALX Oncology's R&D expenses primarily include clinical development costs for evorpacept. For the nine months ended September 30, 2024, clinical and development costs were $50.4 million, a decrease from $70 million in the previous year. Preclinical costs increased to $5.2 million from $2.7 million.

R&D Expenses Q3 2024 Q3 2023 9M 2024 9M 2023
Clinical Development Costs $12.5 million $34.6 million $50.4 million $70 million
Preclinical Costs $2.0 million $1.2 million $5.2 million $2.7 million

Liquidity and Capital Resources

As of September 30, 2024, ALX Oncology had cash, cash equivalents, and investments totaling $162.6 million. The company anticipates that this capital will sustain operations into the first quarter of 2026. Cash used in operating activities for the nine months ended September 30, 2024, was $89.9 million.

Liquidity Metrics 9M 2024 9M 2023
Net Cash Used in Operating Activities $89.9 million $90.7 million
Net Cash Provided by Investing Activities $53.1 million $61.3 million
Net Cash Provided by Financing Activities $30.5 million $0.1 million

Debt Obligations

ALX Oncology has a term loan agreement for up to $100 million. As of September 30, 2024, the outstanding term loan was $9.8 million. The company decided not to draw down an additional $40 million by the June 30, 2024 deadline, which was subsequently added to future available funding milestones.

Debt Obligations Amount
Total Term Loan $9.8 million
Available Milestones $65 million

Stockholder Equity

As of September 30, 2024, the total stockholders' equity was $136.8 million, with an accumulated deficit of $592 million. The company issued 1.8 million shares through its ATM offering program during this period.

Stockholder Equity Amount
Stockholders' Equity $136.8 million
Accumulated Deficit $592 million

Future Outlook

ALX Oncology is focused on advancing evorpacept through clinical trials, aiming for regulatory approval. The company expects to incur increasing expenses as it continues its R&D efforts and operational activities as a public entity.



How ALX Oncology Holdings Inc. (ALXO) Makes Money

Revenue Generation Model

ALX Oncology Holdings Inc. (ALXO) primarily focuses on the development of innovative therapies for cancer treatment. As of 2024, the company has not yet commercialized any product candidates, resulting in a lack of product revenue. The revenue model relies heavily on funding from equity offerings and potential future partnerships.

Funding Sources

  • As of September 30, 2024, ALX Oncology had cash, cash equivalents, and short-term and long-term investments totaling $162.6 million.
  • Since inception, the company raised an aggregate of $642.8 million, primarily through various equity offerings.
  • Recent financing activities included proceeds from an At-the-Market (ATM) offering of $29.3 million.

Research and Development Expenses

The company incurs significant expenses related to research and development (R&D). For the three months ended September 30, 2024, R&D expenses amounted to $26.5 million, while for the nine months, it was $92.8 million. This investment is primarily directed toward advancing its lead product candidate, evorpacept.

Expense Category Three Months Ended September 30, 2024 (in thousands) Three Months Ended September 30, 2023 (in thousands) Nine Months Ended September 30, 2024 (in thousands) Nine Months Ended September 30, 2023 (in thousands)
Research and Development $26,471 $45,766 $92,841 $100,011
General and Administrative $6,096 $7,509 $19,013 $22,244
Total Operating Expenses $32,567 $53,275 $111,854 $122,255

Net Loss and Accumulated Deficit

ALX Oncology reported a net loss of $30.7 million for the three months ended September 30, 2024, compared to a net loss of $51.0 million for the same period in 2023. For the nine months ended September 30, 2024, the net loss was $105.7 million, down from $115.3 million in 2023. As of September 30, 2024, the accumulated deficit stood at $592.0 million.

Interest Income and Expense

Interest income for the three months ended September 30, 2024, was $2.3 million, while interest expense was $446,000. For the nine months of 2024, interest income totaled $7.5 million, with interest expense reaching $1.3 million.

Future Milestones and Obligations

ALX Oncology has established milestone payments related to its collaborations and product development. The company has committed to pay up to $35.0 million in milestones associated with the ScalmiBio technology acquisition. As of September 30, 2024, the future maturities under the Loan Agreement total $10.6 million.

Cash Flow Activity

The net cash used in operating activities for the nine months ended September 30, 2024, was $89.9 million, reflecting the ongoing operational costs and net loss. Cash flow from investing activities for the same period was $53.1 million, primarily due to cash received from maturities of investments.

Cash Flow Activity (in thousands) Nine Months Ended September 30, 2024 Nine Months Ended September 30, 2023
Net cash used in operating activities $(89,866) $(90,686)
Net cash provided by investing activities $53,073 $61,323
Net cash provided by financing activities $30,489 $125

Outlook and Financial Strategy

ALX Oncology aims to continue advancing its clinical programs, particularly evorpacept, and expects to incur substantial operating expenses as it progresses through various stages of development. The company recognizes the ongoing need for capital to support its operations and intends to pursue additional funding avenues as necessary.

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Resources:

  1. ALX Oncology Holdings Inc. (ALXO) Financial Statements – Access the full quarterly financial statements for Q3 2024 to get an in-depth view of ALX Oncology Holdings Inc. (ALXO)' financial performance, including balance sheets, income statements, and cash flow statements.
  2. SEC Filings – View ALX Oncology Holdings Inc. (ALXO)' latest filings with the U.S. Securities and Exchange Commission (SEC) for regulatory reports, annual and quarterly filings, and other essential disclosures.