Autolus Therapeutics plc (AUTL) Bundle
A Brief History of Autolus Therapeutics plc (AUTL)
Foundation and Early Development
Autolus Therapeutics plc was founded in 2014 by Dr. Christian Itin, who served as the CEO. The company was established to develop next-generation -1 T cell therapies for the treatment of cancer. Headquartered in London, the company leverages advanced technology to create safer and more effective therapies.
Initial Funding and Financial Milestones
In November 2014, Autolus raised $30 million in a Series A funding round led by the venture capital firm Syncona. By June 2016, the company secured an additional $50 million in a Series B round. As of 2020, the company went public on the Nasdaq under the ticker symbol AUTL, raising approximately $180 million in its initial public offering (IPO).
| Year | Funding Round | Amount Raised (in $ millions) |
|---|---|---|
| 2014 | Series A | 30 |
| 2016 | Series B | 50 |
| 2020 | IPO | 180 |
Clinical Development and Pipeline
Autolus has developed several product candidates, including AUTO1, AUTO3, and AUTO4. AUTO1 is designed for the treatment of acute lymphoblastic leukemia (ALL), while AUTO3 targets aggressive cancers such as large B-cell lymphoma. As of late 2023, the company is conducting multiple clinical trials across these programs.
Strategic Partnerships and Collaborations
In 2021, Autolus entered a strategic collaboration with the German biotech company, Boehringer Ingelheim, focused on the development of cell therapies. This collaboration aims to enhance the manufacturing processes of Autolus's pipeline products.
Financial Performance and Stock Performance
As of October 2023, Autolus Therapeutics reported a revenue of $25 million for the fiscal year 2022. The company's market capitalization was approximately $300 million. In terms of stock performance, AUTL shares have fluctuated, trading between $5 and $12 throughout 2023.
| Year | Revenue (in $ millions) | Market Capitalization (in $ millions) | Stock Price Range (in $) |
|---|---|---|---|
| 2022 | 25 | 300 | 5 - 12 |
Recent Developments and Future Outlook
In September 2023, Autolus received FDA Fast Track designation for AUTO1 in adult ALL, which is expected to speed up its development and potential approval process. The company aims to expand its clinical trial activities and explore new therapeutic targets in the coming years.
Conclusion
Autolus Therapeutics continues to navigate the complexities of the biotech landscape, focusing on innovative therapies and strategic collaborations to enhance its portfolio.
A Who Owns Autolus Therapeutics plc (AUTL)
Shareholder Structure
The ownership of Autolus Therapeutics plc (AUTL) is categorized into various stakeholders including institutional investors, retail investors, and company insiders. The following table outlines the current ownership distribution as of the latest fiscal report.
| Shareholder Type | Ownership Percentage | Number of Shares |
|---|---|---|
| Institutional Investors | 60.2% | 20,350,000 |
| Insiders | 10.5% | 3,560,000 |
| Retail Investors | 29.3% | 9,900,000 |
Top Institutional Investors
The following table lists the top institutional investors in Autolus Therapeutics plc, including their respective ownership percentages and the number of shares held.
| Investor Name | Ownership Percentage | Number of Shares |
|---|---|---|
| FMR LLC | 8.7% | 2,950,000 |
| BlackRock, Inc. | 7.5% | 2,500,000 |
| Invesco Ltd. | 5.0% | 1,700,000 |
| Vanguard Group, Inc. | 4.8% | 1,600,000 |
Insider Ownership
Insider ownership in Autolus Therapeutics includes key executives and board members. Their holdings demonstrate confidence in the company's potential. The following table provides details about significant insiders and their ownership stakes.
| Name | Position | Ownership Percentage | Number of Shares |
|---|---|---|---|
| Dr. Christian Itin | CEO | 3.4% | 1,150,000 |
| Dr. Aisling McCarthy | CFO | 2.1% | 700,000 |
| Dr. John W. M. L. Hart | Chairman | 1.5% | 500,000 |
Recent Share Performance
As of the latest trading session, Autolus Therapeutics plc (AUTL) has shown notable fluctuations in its share price. The following table summarizes key financial metrics related to share performance.
| Date | Opening Price | Closing Price | Volume |
|---|---|---|---|
| October 23, 2023 | $3.45 | $3.60 | 150,000 |
| October 22, 2023 | $3.40 | $3.45 | 120,000 |
| October 21, 2023 | $3.50 | $3.40 | 100,000 |
Market Capitalization
As of the latest available data, the market capitalization of Autolus Therapeutics plc is calculated at approximately $200 million, based on the latest share price of $3.60 and total shares outstanding.
Historical Ownership Trends
Ownership stakes can fluctuate over time due to trading activity. This table reflects historical ownership percentages recorded over the previous year.
| Time Period | Institutional Investors (%) | Insider Ownership (%) | Retail Ownership (%) |
|---|---|---|---|
| 1 Year Ago | 55.0% | 12.0% | 33.0% |
| 6 Months Ago | 58.0% | 11.0% | 31.0% |
| Current | 60.2% | 10.5% | 29.3% |
Conclusion of Ownership Analysis
The ownership distribution at Autolus Therapeutics plc reveals a strong backing from institutional investors, strategic insider holdings, and a diverse retail investor base. This multifaceted ownership structure can impact the company's strategic decisions and market performance.
Autolus Therapeutics plc (AUTL) Mission Statement
Company Overview
Autolus Therapeutics plc is a clinical-stage biopharmaceutical company focused on developing next-generation, programmed T-cell therapies for the treatment of cancer. The company's mission is centered around advancing the field of cell therapy, with a commitment to innovating and delivering transformative treatments to patients.
Core Mission Components
The mission statement of Autolus Therapeutics encompasses several key components:
- Innovation: Continuously push the boundaries of cell therapy technology.
- Patient Focus: Prioritize the needs and outcomes of patients in cancer treatment.
- Collaboration: Work with leading academic and industry partners to advance research and development.
- Ethical Standards: Maintain high ethical standards in all aspects of operations.
Current Financial Snapshot
As of the latest financial reports in Q2 2023, Autolus Therapeutics reported the following financial data:
| Financial Metric | Amount (in millions USD) |
|---|---|
| Total Revenue | 20.1 |
| Net Loss | (30.2) |
| Cash and Cash Equivalents | 100.4 |
| Total Assets | 150.9 |
| Total Liabilities | 50.6 |
Strategic Objectives
Autolus aims to achieve various strategic objectives to fulfill its mission:
- Advance clinical trials for lead candidates, such as AUTO1 and AUTO3.
- Expand partnerships with pharmaceutical companies and research institutions.
- Enhance manufacturing capabilities to support large-scale production of cell therapies.
- Ensure compliance with regulatory requirements to expedite product approvals.
Clinical Pipeline
The company's clinical pipeline includes a range of T-cell therapy candidates currently in various stages of clinical trials:
| Candidate | Indication | Stage |
|---|---|---|
| AUTO1 | Acute Lymphoblastic Leukemia (ALL) | Phase 2 |
| AUTO3 | Hematological Malignancies | Phase 1 |
| AUTO4 | Solid Tumors | Pre-clinical |
Recent Achievements
In 2023, Autolus achieved significant milestones:
- Clinical trial enrollment exceeded projections by 15%.
- Partnership with a major biotechnology firm valued at $50 million.
- Published findings in leading scientific journals, enhancing credibility.
Market Position
As of Q3 2023, Autolus Therapeutics holds a competitive position in the cell therapy market:
- Market capitalization: $450 million.
- Key competitors include Novartis and Gilead Sciences.
- Growth rate in revenue over the past year is estimated at 25%.
How Autolus Therapeutics plc (AUTL) Works
Company Overview
Autolus Therapeutics plc is a clinical-stage biopharmaceutical company focused on the development of programmed T cell therapies for the treatment of cancer. The company is headquartered in London, United Kingdom, and trades on the NASDAQ under the ticker symbol AUTL.
Core Technologies
Autolus utilizes a proprietary programming platform that focuses on T cell manipulation. The main technology platforms include:
- Autologous T cell therapies: Involves extracting T cells from patients, modifying them in the lab, and infusing them back.
- Next-generation CAR-T therapies: Designed to enhance the efficacy and safety of existing CAR-T treatments.
- Targeted immune modulation: Aims to improve the tumor microenvironment and increase T cell activity.
Pipeline Products
Autolus has multiple product candidates in various stages of clinical development:
| Product Candidate | Indication | Stage of Development | Phase |
|---|---|---|---|
| AUTO1 | B-Cell Malignancies | Clinical | Phase 1/2 |
| AUTO3 | CD19+ Cancers | Clinical | Phase 1 |
| AUTO4 | B-Cell Lymphoma | Preclinical | N/A |
| AUTO6 | Multiple Myeloma | Preclinical | N/A |
Financial Performance
As of the end of Q2 2023, Autolus reported the following financial figures:
| Metric | Value |
|---|---|
| Cash and Cash Equivalents | $86.3 million |
| Revenue | $1.2 million |
| Net Loss | $24.1 million |
| R&D Expenses | $18.5 million |
| SG&A Expenses | $5.6 million |
Market Opportunities
The global CAR-T therapy market was valued at approximately $4.5 billion in 2022, with projections indicating growth to over $20 billion by 2028. Autolus is positioned to leverage its innovative therapies to capture a share of this expanding market.
Partnerships and Collaborations
Autolus has established several collaborations, including:
- Partnership with University College London: Focused on research and development of CAR-T technologies.
- Collaboration with Celgene: Aims to enhance the development and commercialization of CAR-T products.
- Strategic alliance with major pharmaceutical companies: Facilitates access to advanced technologies and resources.
Recent Developments
In recent months, Autolus announced:
- Enrollment of the first patient in the Phase 1 clinical trial for AUTO1 targeting B-cell malignancies.
- Presentation of data at the American Society of Hematology (ASH) Annual Meeting highlighting preliminary efficacy results for AUTO3.
- Expansion of manufacturing capabilities to enhance production capacity for its clinical programs.
How Autolus Therapeutics plc (AUTL) Makes Money
Product Development and Commercialization
Product Development and Commercialization
Autolus Therapeutics focuses on the development and commercialization of innovative T cell therapies for the treatment of cancer. The primary focus is on CAR T-cell therapies, which are engineered to target specific antigens on tumor cells.
Revenue Streams
- Product Sales
- Partnerships and Collaborations
- Grants and Funding
Product Sales
As of 2023, Autolus has commercialized the product OBT-101, generating revenue through the sale of this therapy. For fiscal year 2022, the revenue from product sales amounted to $15 million.
Partnerships and Collaborations
Autolus has entered into strategic partnerships with various biopharmaceutical companies. In 2022, the company secured a collaboration agreement with Bristol-Myers Squibb, which included an upfront payment of $50 million and potential future milestone payments amounting to $400 million.
| Partnership | Upfront Payment | Potential Milestone Payments | Royalty Rate |
|---|---|---|---|
| Bristol-Myers Squibb | $50 million | $400 million | Mid-single digits |
| Gilead Sciences | $30 million | $300 million | Low double digits |
Grants and Funding
In addition to product sales and collaborations, Autolus receives funding through grants. In 2023, the company reported receiving a total of $10 million from various government and private foundations aimed at supporting innovative cancer therapies.
Financial Performance
For the fiscal year ended December 31, 2022, Autolus reported a net loss of $65 million, with total operating expenses of $75 million. Their cash and cash equivalents at the end of 2022 were approximately $150 million.
| Financial Metric | Amount (2022) |
|---|---|
| Revenue | $15 million |
| Net Loss | ($65 million) |
| Total Operating Expenses | $75 million |
| Cash and Cash Equivalents | $150 million |
Market Position and Future Outlook
As of October 2023, Autolus Therapeutics is positioned within the competitive landscape of CAR T-cell therapy, where the estimated market size for CAR T-cell therapies is projected to reach $12 billion by 2028. Autolus aims to leverage its innovative approaches to capture a significant share of this growing market.
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