BeyondSpring Inc. (BYSI) Bundle
A Brief History of BeyondSpring Inc. (BYSI)
Founding and Early Years
BeyondSpring Inc. was founded in 2010 by Dr. Lan Huang in New York City. The company was initially focused on the development of innovative oncology therapeutics. The mission was to enhance the effectiveness and safety of cancer treatments through its proprietary technology.
Initial Public Offering
BeyondSpring went public on the NASDAQ under the ticker symbol BYSI on December 18, 2019. The initial offering priced at $15 per share raised approximately $75 million, helping to fund its clinical trials and development projects.
Clinical Development Pipeline
The company's primary product candidate, BYSI-301, is designed to address chemotherapy-induced neutropenia, a common side effect of cancer treatment. As of 2021, BeyondSpring had initiated multiple clinical trials for BYSI-301, aiming to demonstrate its efficacy compared to existing treatments.
| Year | Milestone | Clinical Trials | Funding Raised |
|---|---|---|---|
| 2010 | Founded | N/A | N/A |
| 2019 | IPO | Initial funding | $75 million |
| 2021 | Phase III Trials | Two for BYSI-301 | N/A |
Financial Performance
As of the end of Q3 2023, BeyondSpring reported revenue of approximately $4 million. The company's net loss for the same period was reported as $22 million, showing an increase compared to $18 million in net loss during Q3 2022.
| Financial Metric | 2021 | 2022 | 2023 (Q3) |
|---|---|---|---|
| Revenue | $1 million | $3 million | $4 million |
| Net Loss | $15 million | $18 million | $22 million |
| Cash on Hand | $100 million | $80 million | $60 million |
Recent Developments
In April 2023, BeyondSpring announced encouraging results from its Phase III trial for BYSI-301, indicating a significant reduction in the incidence of febrile neutropenia in patients receiving chemotherapy. The stock price surged by 40% following the announcement.
Market Presence and Collaboration
BeyondSpring has established collaborations with several pharmaceutical companies to leverage combined expertise in drug development. The company has also engaged in partnerships to enhance its research capabilities and accelerate the drug development process.
- Key Partnerships:
- AstraZeneca
- Novartis
- Pfizer
- Conferences Attended:
- American Society of Clinical Oncology (ASCO)
- European Society for Medical Oncology (ESMO)
- World Congress on Cancer
Stock Performance
As of October 2023, BeyondSpring's stock price was approximately $5.20 per share, down from a high of $25 per share in early 2022. The company has seen volatility, with fluctuations largely driven by trial results and partnership announcements.
Outlook
BeyondSpring continues to focus on advancing its clinical pipeline and exploring new opportunities in oncology. The management has expressed optimism about the upcoming milestones in 2024, including the potential filing for regulatory approval based on positive trial outcomes.
A Who Owns BeyondSpring Inc. (BYSI)
Ownership Structure
Ownership Structure
As of the latest report, BeyondSpring Inc. has a diverse ownership structure comprising institutional investors, retail investors, and company insiders. The following table provides a breakdown of the ownership percentages attributed to various stakeholders:
| Owner Type | Ownership Percentage |
|---|---|
| Institutional Investors | 55% |
| Retail Investors | 30% |
| Company Insiders | 15% |
Major Institutional Investors
The following table outlines some of the key institutional investors in BeyondSpring Inc. with their respective ownership stakes:
| Institution | Ownership Percentage |
|---|---|
| BlackRock, Inc. | 10% |
| The Vanguard Group, Inc. | 8% |
| State Street Corporation | 7% |
| Invesco Ltd. | 5% |
| Goldman Sachs Group, Inc. | 4% |
Company Insider Ownership
Insider ownership is significant at BeyondSpring Inc. The current executive team and board of directors hold the following percentages of the company's shares:
| Name | Position | Ownership Percentage |
|---|---|---|
| Dr. Lan Huang | Chairman & CEO | 6% |
| Dr. Sherri J. Rosen | President & COO | 4% |
| John A. O’Brien | CFO | 2% |
| Board of Directors | Various Members | 3% |
Recent Financial Performance
BeyondSpring Inc. has shown notable financial metrics in its recent filings. The following table summarizes key financial figures for the most recent fiscal year:
| Financial Metric | Value (in million USD) |
|---|---|
| Total Revenue | 25 |
| Net Loss | -10 |
| Cash and Cash Equivalents | 15 |
| Total Assets | 50 |
| Total Liabilities | 30 |
Recent Shareholder Changes
Recent filings indicate changes in major shareholders for BeyondSpring Inc. The following table provides insights into significant shareholder movements:
| Shareholder | Change in Ownership (percentage points) | Date |
|---|---|---|
| BlackRock, Inc. | -2 | Q3 2023 |
| State Street Corporation | +1 | Q3 2023 |
| Dr. Lan Huang | +1 | Q3 2023 |
Stock Performance
BeyondSpring Inc.'s stock has experienced fluctuations. The following statistics summarize its stock performance over the last year:
| Metric | Value |
|---|---|
| Current Stock Price (as of October 2023) | $6.50 |
| 52-Week High | $10.00 |
| 52-Week Low | $5.00 |
| Market Capitalization | $200 million |
BeyondSpring Inc. (BYSI) Mission Statement
Core Mission
BeyondSpring Inc. aims to transform the oncology landscape by developing innovative therapies that significantly improve patients' lives. The company focuses on addressing unmet medical needs and enhancing the standard of care through advanced biopharmaceutical solutions.
Key Objectives
- Development of breakthrough therapies for cancer treatment.
- Commitment to patient safety and efficacy in clinical trials.
- Partnership with healthcare professionals to improve treatment accessibility.
- Focus on sustainability and ethical practices in research and development.
- Achieving commercial success to reinvest in further innovative research.
Financial Overview
As of the latest financial report, BeyondSpring Inc. has reported the following figures:
| Financial Metric | Value (USD) |
|---|---|
| Market Capitalization | Approximately $305 million |
| Total Assets | $64.43 million |
| Total Revenue (2022) | $2.5 million |
| Total Net Income (2022) | $(32.36) million |
| R&D Expenses (2022) | $23.19 million |
| Cash and Cash Equivalents | $29.57 million |
| Debt | $7.44 million |
Strategic Partnerships
BeyondSpring Inc. emphasizes the importance of collaborations in achieving its mission. Recent strategic partnerships include:
| Partner | Type of Collaboration | Year Established |
|---|---|---|
| Antengene Corporation | Co-development of innovative oncology therapies | 2020 |
| Memorial Sloan Kettering Cancer Center | Clinical trial collaboration | 2019 |
| National Institutes of Health (NIH) | Research funding and collaboration | 2021 |
Future Goals
BeyondSpring Inc. is focused on several key areas for expansion and development:
- Advancing pipeline products through clinical trials.
- Exploring international markets for greater reach.
- Enhancing patient education and support programs.
- Investing in cutting-edge research technologies.
- Strengthening intellectual property portfolio.
Patient-Centric Approach
BeyondSpring Inc. underscores its commitment to a patient-centric approach by:
- Engaging with patient advocacy groups.
- Utilizing real-world evidence to inform product development.
- Implementing feedback mechanisms from patients in clinical trials.
How BeyondSpring Inc. (BYSI) Works
Overview of BeyondSpring Inc.
BeyondSpring Inc. is a clinical-stage biopharmaceutical company that focuses on the development of innovative cancer therapies. Its lead product candidate is plinabulin, which targets a range of malignancies, including non-small cell lung cancer (NSCLC) and breast cancer.
Business Model
The company operates on a model that emphasizes research and development (R&D) in immuno-oncology. BeyondSpring partners with various institutions to leverage existing scientific advancements and integrate them into their therapeutic approaches.
Key Products
- Plinabulin
- BeyondSpring's pipeline also includes drugs targeting other cancers, emphasizing both efficacy and safety.
Financial Performance
As of the last reported fiscal year, BeyondSpring reported revenues of approximately $1.9 million in 2022, derived primarily from grants and collaborations. The company reported a net loss of $54.8 million for the same year.
Stock Performance and Market Data
As of October 2023, BeyondSpring's stock (BYSI) is trading at approximately $1.20 per share. The market capitalization stands around $55 million.
Research and Development Expenditure
For the fiscal year 2022, research and development expenses were reported at $35 million, accounting for about 64% of total expenditures. Administrative expenses reached $12 million during the same period.
Collaboration and Partnerships
BeyondSpring has entered into various collaborations, notably with academic institutions and pharmaceutical corporations to enhance its R&D capabilities. These partnerships often include milestone payments and revenue-sharing agreements.
Pipeline Overview
| Product Candidate | Indication | Phase of Development | Expected Milestone |
|---|---|---|---|
| Plinabulin | NSCLC | Phase 3 | FDA Submission by 2024 |
| Plinabulin | Breast Cancer | Phase 2 | Data Readout in 2023 |
| Other Candidates | Various Cancers | Preclinical | Ongoing Research |
Regulatory Pathways
BeyondSpring ensures compliance with FDA regulations and guidelines throughout its development process. The company is actively working on obtaining orphan drug designation for its key product candidates, which can provide significant commercial advantages.
Investor Relations
BeyondSpring’s investor relations strategy focuses on transparency and regular updates regarding clinical trial progress and financial performance. The company conducts quarterly earnings calls and participates in investor conferences.
Recent Financial Data
| Financial Metric | 2022 | 2021 |
|---|---|---|
| Total Revenue | $1.9 million | $0.5 million |
| Net Loss | $54.8 million | $47.5 million |
| R&D Expenses | $35 million | $28 million |
| Cash Position | $53 million | $75 million |
Market Considerations
The biopharmaceutical sector exhibits volatility, influenced by clinical trial results, regulatory approvals, and broader market conditions. BeyondSpring navigates these challenges through strategic planning and continuous assessment of market trends.
Competitive Landscape
BeyondSpring faces competition from other biotech firms focusing on immuno-oncology, including but not limited to companies with approved therapies or late-stage candidates. The competitive environment necessitates ongoing innovation and differentiation in product offerings.
How BeyondSpring Inc. (BYSI) Makes Money
Revenue Streams
Revenue Streams
BeyondSpring Inc. generates revenue primarily through the development and commercialization of its biopharmaceutical products. The key product in their pipeline is ypa-51, which is in clinical trials for treating cancer.
Clinical Trials and Partnerships
Revenue comes from collaborations and licensing agreements with larger pharmaceutical companies. As of 2023, BeyondSpring entered a strategic partnership with Novartis to develop therapies for solid tumors. The estimated value of this deal is $175 million, which includes upfront payments and milestone payments.
Product Sales
BeyondSpring's revenue is also anticipated from the potential commercialization of its drugs if they receive FDA approval. As of the latest reports, the projected annual revenue from ypa-51 post-approval could reach $1 billion by 2025 based on similar drugs in the market.
Financial Performance
In the fiscal year 2022, BeyondSpring reported revenue of $1 million, a significant increase from $150,000 in 2021. Their operating expenses were reported at $45 million, leading to a net loss of $44 million.
Table of Financials
| Fiscal Year | Revenue ($ million) | Operating Expenses ($ million) | Net Loss ($ million) |
|---|---|---|---|
| 2021 | 0.15 | 35 | 34.85 |
| 2022 | 1 | 45 | 44 |
| 2023 (Projected) | 2 | 50 | 48 |
Future Revenue Projections
Future revenues may also stem from royalties and sales from licensed products. Current projections estimate that BeyondSpring could earn up to 15% royalties on sales generated by partnered products.
Market Potential
The global oncology market is expected to reach $200 billion by 2025, with targeted therapies being a significant component. BeyondSpring aims to capture a share of this market as their products advance through clinical trials.
Investment and Capital Raises
In 2023, BeyondSpring raised $25 million in a public offering to fund ongoing clinical trials and operational costs. This capital is vital for maintaining their research and development efforts.
Table of Investment Rounds
| Year | Round | Amount Raised ($ million) |
|---|---|---|
| 2020 | Series A | 15 |
| 2021 | Series B | 20 |
| 2023 | Public Offering | 25 |
Regulatory Milestones
Successful completion of regulatory milestones can also lead to additional financial inflows. BeyondSpring is currently waiting for FDA approval, which, if granted in 2024, will trigger milestone payments from partners.
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