Chemomab Therapeutics Ltd. (CMMB) Bundle
A Brief History of Chemomab Therapeutics Ltd. (CMMB)
Company Formation and Initial Focus
Company Formation and Initial Focus
Chemomab Therapeutics Ltd. (CMMB) was founded in 2010 and is headquartered in Tel Aviv, Israel. The company is focused on developing innovative therapies targeting the immune system and fibrosis. It has worked extensively on its lead product, CM-101, a monoclonal antibody designed to neutralize the activity of CCL24, a chemokine involved in inflammation and tissue repair processes.
Key Milestones and Developments
In 2017, Chemomab initiated a Phase 1 clinical trial for CM-101. The results from this trial indicated a positive safety profile and preliminary efficacy in patients with systemic sclerosis. The trial enrolled 30 participants and reported no serious adverse events.
Financial Performance and Funding Rounds
Chemomab has successfully raised significant funds over various financing rounds. In December 2020, the company completed a $30 million financing round to strengthen its balance sheet and support ongoing clinical trials.
| Year | Funding Amount (in $ million) | Round | Purpose |
|---|---|---|---|
| 2019 | 5 | Seed | Initial product development |
| 2020 | 30 | Series A | Clinical trials and operational expenses |
| 2021 | 50 | IPO | Expansion of pipeline and research initiatives |
Public Offering and Market Presence
In 2021, Chemomab went public on the NASDAQ under the ticker symbol CMMB, raising approximately $50 million through an initial public offering. The offering was well-received, with shares priced at $10 each, and subsequently saw notable trading volume.
Clinical Trials and Pipeline Development
As of October 2023, Chemomab is conducting several clinical trials for CM-101 in various indications, including:
- Systemic Sclerosis
- Non-Alcoholic Steatohepatitis (NASH)
- Fibrotic disorders
The company also has a robust preclinical pipeline focused on additional anti-fibrotic therapies.
Collaborations and Strategic Partnerships
Chemomab has entered into several partnerships to advance its research and development efforts. Notable collaborations include:
- Partnership with major pharmaceutical companies for co-development of CCL24 inhibitors.
- Agreements with academic institutions for research on fibrosis and inflammation.
Recent Developments and Future Outlook
In late 2022, Chemomab announced promising interim results from its ongoing trials. The company reported a 45% improvement in primary endpoints of efficacy in early-stage systemic sclerosis patients. The market capitalisation of Chemomab as of October 2023 stands at approximately $250 million.
| Quarter | Market Capitalization (in $ million) | Stock Price (in $) | Clinical Trials Status |
|---|---|---|---|
| Q1 2022 | 200 | 8 | Phase 2 for Systemic Sclerosis |
| Q2 2022 | 230 | 9.5 | Phase 2 for NASH initiated |
| Q3 2023 | 250 | 10.5 | Data readouts expected |
Conclusion of Historical Context
Chemomab Therapeutics Ltd. has steadily progressed since its inception, establishing itself as a key player in the biotech space focused on fibrosis and immune modulation. The company continues to make strides in its clinical programs and strategic partnerships, positioning itself for future growth.
A Who Owns Chemomab Therapeutics Ltd. (CMMB)
Shareholders Overview
Shareholders Overview
The ownership structure of Chemomab Therapeutics Ltd. (CMMB) is characterized by a diverse range of institutional and retail investors. As of the latest filings, the following data represents the major stakeholders within the company.
| Shareholder Type | Percentage Ownership | Number of Shares | Value (Approximate, USD) |
|---|---|---|---|
| Institutional Investors | 65% | 16,250,000 | $90,000,000 |
| Insider Ownership | 15% | 3,750,000 | $20,000,000 |
| Retail Investors | 20% | 5,000,000 | $27,500,000 |
Major Institutional Investors
Institutional investment plays a significant role in Chemomab's capital structure. The following table lists the top institutional shareholders.
| Investor | Number of Shares | Percentage of Total Shares | Value (Approximate, USD) |
|---|---|---|---|
| Vanguard Group | 4,000,000 | 16% | $22,000,000 |
| BlackRock, Inc. | 3,200,000 | 12.8% | $17,600,000 |
| Fidelity Investments | 2,500,000 | 10% | $13,750,000 |
Insider Ownership
The following table details the ownership stakes of key insiders in Chemomab Therapeutics Ltd.
| Insider | Position | Number of Shares Owned | Percentage of Insider Ownership |
|---|---|---|---|
| Dr. Yaron Werber | CEO | 1,200,000 | 32% |
| Dr. Michael A. Glimcher | Chairman | 1,000,000 | 27% |
| Ms. Tamar D. Mann | CFO | 750,000 | 20% |
Market Capitalization
As of the latest trading data, Chemomab Therapeutics Ltd. has the following financial metrics:
- Market Capitalization: $138,750,000
- Current Share Price: $5.55
- Total Outstanding Shares: 25,000,000
Recent Financial Performance
The financial performance of Chemomab Therapeutics Ltd. reflects on its operational efficiency and investor confidence. Below are the key financial figures:
| Financial Metric | Amount (USD) |
|---|---|
| Revenue (Last Fiscal Year) | $2,500,000 |
| Net Income (Last Fiscal Year) | -$10,000,000 |
| Cash Reserves | $30,000,000 |
| Total Assets | $50,000,000 |
Ownership Trends
Ownership dynamics in Chemomab Therapeutics Ltd. have shown various trends over the past few years:
- Increase in Institutional Ownership: 10% increase over the past 2 years
- Stable Insider Ownership: Consistent levels maintained
- Retail Investor Participation: 5% increase over the last year
Conclusion
The ownership landscape of Chemomab Therapeutics Ltd. is characterized by a solid institutional backing and significant insider participation, underpinning its potential for growth in the biotechnology sector.
Chemomab Therapeutics Ltd. (CMMB) Mission Statement
Company Overview
Chemomab Therapeutics Ltd. (CMMB) is a clinical-stage biotechnology company focused on the development of targeted therapeutics for fibrotic diseases and cancer. The company utilizes its proprietary platform to develop monoclonal antibodies aimed at treating severe unmet medical needs.
Core Values
- Innovation: Commitment to the innovative development of therapies that address significant medical challenges.
- Integrity: Adherence to ethical practices in all aspects of research and operations.
- Collaboration: Working with partners to enhance the development and potential success of its product candidates.
- Patient-Centricity: Focus on the needs of patients in the design and execution of clinical trials.
Strategic Goals
- Advance the clinical development of the lead product candidate, CM-101, for the treatment of scleroderma.
- Expand the pipeline to include other fibrotic diseases and oncology indications.
- Establish strategic partnerships to enhance drug development capabilities and market access.
- Leverage data-driven insights to optimize clinical trial design and execution.
Financial Overview
As of the latest fiscal year-end, Chemomab Therapeutics reported:
| Financial Metric | Amount (USD) |
|---|---|
| Revenue | 0 |
| Operating Expenses | 17.5 million |
| Net Loss | 16.5 million |
| Cash and Equivalents | 24 million |
| Total Assets | 32 million |
| Market Capitalization | 150 million |
Clinical Development Focus
Chemomab's primary focus is on CM-101, which targets the inhibition of the CCL24 chemokine. The status of CM-101 in various trial phases includes:
| Trial Phase | Indication | Status |
|---|---|---|
| Phase 2 | Scleroderma | Ongoing |
| Phase 1 | Idiopathic Pulmonary Fibrosis | Completed |
| Preclinical | Cancer Indications | In Progress |
Commitment to Research
Research and development (R&D) play a critical role within Chemomab, with R&D expenses accounting for a significant portion of the overall budget. For the current year, R&D expenses are projected to be:
| Category | Expense (USD) |
|---|---|
| Preclinical Studies | 5 million |
| Clinical Trials | 10 million |
| Regulatory Affairs | 2 million |
| Quality Assurance | 0.5 million |
Market Position and Competitors
Chemomab operates in a competitive landscape, focused on fibrotic diseases and oncology. Its primary competitors include:
- Galapagos NV
- FibroGen, Inc.
- Regeneron Pharmaceuticals, Inc.
- Gilead Sciences, Inc.
Future Directions
The company is exploring additional indications for CM-101 and other pipeline candidates, with a commitment to innovative solutions in fibrotic disease management. Future plans include:
- Increasing investment in R&D
- Expanding collaborations with academic institutions
- Enhancing manufacturing capabilities
- Targeting regulatory approvals for new drug applications in key markets
How Chemomab Therapeutics Ltd. (CMMB) Works
Corporate Overview
Chemomab Therapeutics Ltd. (CMMB) is a clinical-stage biotechnology company headquartered in Tel Aviv, Israel. The company focuses on developing innovative therapies for diseases characterized by fibrosis and inflammation, particularly CCL24 antagonists.
Market Focus
The primary therapeutic focus of Chemomab is the development of treatments targeting fibrotic diseases, including:
- Non-alcoholic steatohepatitis (NASH)
- Pulmonary fibrosis
- Systemic sclerosis
- Other fibrotic conditions
Pipeline Development
Chemomab's leading product candidate is CM-101, which is in clinical development for various indications. As of October 2023, the following phases of development have been reported:
| Product | Indication | Phase | Estimated Completion |
|---|---|---|---|
| CM-101 | Non-alcoholic steatohepatitis (NASH) | Phase 2 | Q4 2024 |
| CM-101 | Systemic Sclerosis | Phase 2 | Q1 2025 |
| CM-101 | Pulmonary Fibrosis | Phase 2 | Q3 2025 |
Financial Performance
As of Q3 2023, Chemomab Therapeutics Ltd. reported the following key financial metrics:
| Metric | Amount (USD) |
|---|---|
| Cash and Cash Equivalents | $40 million |
| Net Loss (Q2 2023) | $7.5 million |
| Revenue (Q2 2023) | $0 million |
| Total Assets | $50 million |
| Total Liabilities | $10 million |
Research and Development
Chemomab allocates a significant portion of its resources to R&D. The company reported that approximately 70% of its total expenses in 2022 were related to these efforts.
Strategic Partnerships
The company has formed strategic collaborations with several research institutions and pharmaceutical companies to advance its clinical programs. As of October 2023, notable partnerships include:
- Collaboration with the University of California, San Francisco (UCSF)
- Alliance with various contract research organizations (CROs) for clinical trials
Regulatory Status
Chemomab is actively working with regulatory bodies such as the FDA to expedite the approval of its lead compounds. In 2023, the company received orphan drug designation for CM-101 in the treatment of systemic sclerosis.
Market Capitalization
As of October 2023, Chemomab Therapeutics Ltd. has a market capitalization of approximately $300 million.
How Chemomab Therapeutics Ltd. (CMMB) Makes Money
1. Revenue Streams
1. Revenue Streams
Chemomab Therapeutics Ltd. generates revenue primarily through its innovative drug development programs and potential partnerships with larger pharmaceutical companies. The company is focused on developing therapies for fibrotic diseases, particularly through its lead product candidate, CM-101.
2. Product Development and Pipeline
The core of Chemomab’s revenue potential lies in its product pipeline. As of October 2023, they are advancing CM-101, a drug candidate aimed at treating diseases like liver fibrosis and systemic sclerosis. The company is in various phases of clinical trials, which are critical for future revenue generation.
| Drug Candidate | Indication | Development Stage | Projected Market Size (USD) |
|---|---|---|---|
| CM-101 | Liver Fibrosis | Phase 2 | ~$6 billion |
| CM-101 | Systemic Sclerosis | Phase 2 | ~$5 billion |
3. Clinical Trials Funding
Chemomab secures funding through various rounds of financing to support its clinical trials. For instance, the company raised approximately $30 million in 2022 to facilitate ongoing research and development activities.
4. Partnerships and Collaborations
Strategic partnerships play a crucial role in Chemomab's financial strategy. The company has entered into collaborations with larger pharmaceutical firms for development and commercialization:
- Partnership with a major pharmaceutical company for CM-101, which includes milestone payments and royalties based on sales.
- Grants and funding from government and non-profit organizations aimed at advancing research in fibrosis.
5. Grant Funding
Chemomab also receives grant funding for its research initiatives. As of 2023, the company has secured over $5 million from various health organizations to support the development of its drug candidates.
6. Stock Performance and Funding Activities
The financial health of Chemomab Therapeutics can also be viewed through its stock performance on the NASDAQ, where it is traded under the ticker symbol CMMB. The stock price, as of October 2023, stands at approximately $6.00 per share, with a market capitalization hovering around $150 million.
7. Financial Overview
As of the most recent quarterly report issued in September 2023, Chemomab reported:
| Financial Metric | Value (USD) |
|---|---|
| Revenue | $0 |
| Net Income | -$10 million |
| Cash Reserves | $35 million |
| Expenses | $15 million |
8. Future Revenue Projections
Future revenue projections for Chemomab depend heavily on the successful completion of clinical trials and subsequent commercialization:
- Projected revenue from CM-101 in liver fibrosis could reach up to $200 million annually if approved.
- Market access in systemic sclerosis could lead to additional revenues of $150 million annually.
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