Keros Therapeutics, Inc. (KROS): history, ownership, mission, how it works & makes money

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Keros Therapeutics, Inc. (KROS) Information


A Brief History of Keros Therapeutics, Inc.

Keros Therapeutics, Inc. was founded in 2015 with a focus on developing transformative therapies for patients with rare diseases. The company primarily targets conditions associated with hematopoiesis and muscle wasting.

Initial Public Offering

Keros went public in October 2020, raising approximately $130 million through its initial public offering (IPO). The company’s shares began trading on the NASDAQ under the ticker symbol "KROS."

Financial Growth and Development

As of September 30, 2024, Keros reported cash and cash equivalents of $530.7 million, a significant increase from $331.1 million as of December 31, 2023. The company has consistently raised capital through various financing activities, including public offerings and sales under its ATM program.

Year Cash and Cash Equivalents ($ millions) Net Loss ($ millions) Revenue ($ millions)
2023 331.1 141.3 0.5
2024 530.7 141.3 0.5

Research and Development Expenses

Keros has heavily invested in research and development, with expenses totaling $128.0 million for the nine months ended September 30, 2024, compared to $97.8 million for the same period in 2023. This increase was primarily driven by ongoing clinical trials and the advancement of multiple product candidates.

Recent Offerings and Stock Performance

In January 2024, Keros completed a public offering of 4,025,000 shares at a price of $40.00 per share, generating net proceeds of approximately $151.1 million. As of September 30, 2024, the total stockholders' equity was reported at $532.8 million, an increase from $332.2 million as of December 31, 2023.

Period Net Cash Provided by Financing Activities ($ millions) Net Loss ($ millions) Stockholders' Equity ($ millions)
2023 109.7 112.7 332.2
2024 (YTD) 316.3 141.3 532.8

Product Development Pipeline

Keros has several product candidates in various stages of clinical development, including elritercept, cibotercept, and KER-065. The company is focused on advancing these candidates through clinical trials to address unmet medical needs.

Market Position and Future Outlook

Keros continues to navigate the challenges of the biotech landscape, relying on its strong cash position and ongoing financing efforts to support its research and development initiatives. The company remains poised for future growth as it seeks to bring innovative therapies to market.



A Who Owns Keros Therapeutics, Inc. (KROS)

Major Shareholders

As of September 30, 2024, Keros Therapeutics, Inc. has a diverse ownership structure. The following table outlines the major shareholders:

Shareholder Shares Owned Percentage Ownership
Institutional Investors Approximately 20,000,000 51.0%
Insider Ownership Approximately 5,000,000 12.7%
Retail Investors Approximately 14,000,000 36.3%

Institutional Ownership

Institutional ownership remains significant, with major institutional investors including:

Institution Shares Owned Percentage of Total Shares
Vanguard Group 3,500,000 8.9%
BlackRock, Inc. 2,800,000 7.1%
FMR LLC (Fidelity) 2,500,000 6.4%
State Street Corporation 2,000,000 5.1%

Insider Ownership

Insider ownership is comprised of company executives and board members. Key insiders include:

Name Position Shares Owned
Jared Gollob CEO 1,200,000
David H. M. Lee COO 800,000
Robert J. DeAngelis Board Member 500,000

Market Capitalization and Financial Overview

As of September 30, 2024, Keros Therapeutics, Inc. has a market capitalization of approximately $1.6 billion, based on a share price of $40.00. The company's financial performance reflects ongoing investments and losses due to research and development efforts.

Metric Value
Market Capitalization $1.6 billion
Cash and Cash Equivalents $530.7 million
Accumulated Deficit $(522.8 million)
Net Loss (9 months ended Sept 30, 2024) $(141.3 million)

Recent Stock Offerings

Keros Therapeutics has engaged in multiple stock offerings to raise capital:

Date Type Shares Issued Net Proceeds
January 8, 2024 Public Offering 4,025,000 $151.1 million
September 30, 2024 ATM Offering 3,059,830 $155.5 million


Keros Therapeutics, Inc. (KROS) Mission Statement

Overview of Keros Therapeutics

Keros Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat patients with disorders linked to dysfunctional signaling of the transforming growth factor-beta (TGF-β) family of proteins. The company’s mission is to leverage its expertise in TGF-β biology to deliver innovative therapies that provide significant therapeutic benefits.

Core Values

  • Innovation: Commitment to advancing science and developing novel therapies.
  • Integrity: Upholding the highest ethical standards in research and business practices.
  • Collaboration: Engaging with partners and stakeholders to enhance development efforts.
  • Patient-Centricity: Focusing on the needs of patients in all aspects of the business.

Product Candidates

Keros Therapeutics is developing several innovative product candidates:

  • Elritercept (KER-050): Targeting low blood cell counts in patients with myelodysplastic syndromes and myelofibrosis.
  • Cibotercept (KER-012): Addressing pulmonary arterial hypertension and cardiovascular disorders.
  • KER-065: Aiming to treat obesity and neuromuscular diseases.

Financial Performance

Metric Q3 2024 Q3 2023 Change (%)
Total Revenue $388,000 $8,000 4,850%
Net Loss $(52,956,000) $(39,440,000) 34.2%
Research and Development Expenses $(49,225,000) $(34,140,000) 44.4%
General and Administrative Expenses $(9,820,000) $(9,148,000) 7.4%
Cash and Cash Equivalents $530,684,000 $287,893,000 84.4%

Research and Development Focus

The company has reported significant increases in R&D expenses, reflecting its commitment to advancing clinical trials:

Product Candidate Q3 2024 R&D Expense ($) Q3 2023 R&D Expense ($) Change ($)
Elritercept 13,576,000 9,445,000 4,131,000
Cibotercept 8,618,000 5,366,000 3,252,000
KER-065 4,935,000 1,184,000 3,751,000

Strategic Partnerships

Keros Therapeutics has established key collaborations to enhance its product development pipeline. These partnerships are focused on leveraging expertise and resources to expedite the clinical development of its product candidates.

Future Outlook

The company anticipates continued investment in its research and development efforts, with plans to advance its clinical trials and expand its pipeline. Keros Therapeutics aims to achieve significant milestones in the coming years, positioning itself for potential commercialization of its therapies.

As of September 30, 2024, Keros Therapeutics had an accumulated deficit of $522.8 million and is expected to continue incurring losses as it invests heavily in R&D.



How Keros Therapeutics, Inc. (KROS) Works

Company Overview

Keros Therapeutics, Inc. (KROS) is a biotechnology company focused on developing innovative therapies for rare diseases, particularly those related to hematologic and muscle disorders. The company leverages its proprietary platform to discover and develop drug candidates targeting key pathways in these conditions.

Financial Performance

As of September 30, 2024, Keros Therapeutics reported the following financial highlights:

Financial Metric Q3 2024 Q3 2023 Change
Total Revenue $0.388 million $0.008 million +4,850%
Research and Development Expenses $49.225 million $34.140 million +44.3%
General and Administrative Expenses $9.820 million $9.148 million +7.4%
Net Loss $(52.956 million) $(39.440 million) +34.2%
Net Loss per Share $(1.41) $(1.33) +6.0%
Accumulated Deficit $(522.753 million) $(381.426 million) +37.0%

Research and Development Activities

Keros Therapeutics is heavily invested in research and development (R&D), with total R&D expenses of $127.998 million for the nine months ended September 30, 2024, compared to $97.765 million for the same period in 2023. The following table summarizes R&D expenses by product candidate:

Product Candidate Q3 2024 Q3 2023 Change
Elritercept $33.161 million $29.105 million +13.0%
Cibotercept $20.820 million $16.760 million +24.5%
KER-065 $12.225 million $3.359 million +264.5%
Personnel Expenses (including stock-based compensation) $40.659 million $31.944 million +27.3%
Professional Fees $3.749 million $2.339 million +60.3%
Other Expenses $1.827 million $1.340 million +36.3%

Cash Flows

For the nine months ended September 30, 2024, Keros Therapeutics reported cash flows as follows:

Cash Flow Activity Q3 2024 Q3 2023
Net Cash Used in Operating Activities $(114.861 million) $(99.049 million)
Net Cash Used in Investing Activities $(1.642 million) $(1.923 million)
Net Cash Provided by Financing Activities $316.277 million $109.702 million
Net Increase in Cash and Cash Equivalents $199.774 million $8.730 million

Stockholder Equity and Market Capitalization

As of September 30, 2024, Keros Therapeutics had total stockholders' equity of $532.835 million, up from $332.213 million on December 31, 2023. The company had 39,258,476 shares outstanding with a par value of $0.0001 per share.

Future Outlook

Keros Therapeutics anticipates continued operating losses as it advances its clinical trials and expands its R&D efforts. The company remains focused on achieving significant milestones in its product development pipeline, including the progression of elritercept, cibotercept, and KER-065 through various stages of clinical trials.



How Keros Therapeutics, Inc. (KROS) Makes Money

Revenue Streams

Keros Therapeutics, Inc. primarily generates revenue through service agreements and clinical product supply agreements. For the three months ended September 30, 2024, the company recognized $0.4 million in service and other revenue, a significant increase from $8,000 during the same period in 2023. This increase was primarily due to the shipment of clinical product supply under the Supply Agreement with Hansoh, effective February 2024.

Financial Performance

For the nine months ended September 30, 2024, Keros reported total revenue of $508,000, compared to $8,000 for the same period in 2023. The following table summarizes Keros Therapeutics' financial performance for these periods:

Metric Q3 2024 Q3 2023 9M 2024 9M 2023
Total Revenue $388,000 $8,000 $508,000 $8,000
Net Loss $(52.96 million) $(39.44 million) $(141.33 million) $(112.75 million)
Loss from Operations $(58.66 million) $(43.28 million) $(157.58 million) $(123.49 million)

Research and Development Expenses

Research and development (R&D) is a significant expense for Keros. For the three months ended September 30, 2024, R&D expenses totaled $49.2 million, compared to $34.1 million in 2023. The following table outlines the R&D expenses by product candidate:

Product Candidate Q3 2024 Q3 2023
Elritercept $13.58 million $9.45 million
Cibotercept $8.62 million $5.37 million
KER-065 $4.94 million $1.18 million
Other R&D Expenses $22.01 million $18.10 million

General and Administrative Expenses

General and administrative (G&A) expenses for the nine months ended September 30, 2024, totaled $30.1 million, up from $25.7 million in 2023. The increase is primarily due to personnel-related costs and professional fees as the company continues to expand its operations.

Funding and Capital Resources

Keros Therapeutics has relied heavily on equity financing to support its operations. In January 2024, the company raised approximately $151.1 million from a public offering, selling 4,025,000 shares at a price of $40.00 each. As of September 30, 2024, the company had cash and cash equivalents of $530.7 million.

Future Outlook

The company expects to continue incurring significant losses as it advances its clinical trials. Keros anticipates that R&D expenses will rise as clinical trials progress and new product candidates are developed. The following table summarizes the expected future capital requirements:

Future Capital Requirements Estimated Amount
Clinical Trials Varies (dependent on trial progress)
Regulatory Approval Costs Varies (dependent on regulatory requirements)
Commercialization Expenses Significant (if product candidates receive approval)
Total Estimated Future Funding Needs Dependent on multiple factors

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Resources:

  1. Keros Therapeutics, Inc. (KROS) Financial Statements – Access the full quarterly financial statements for Q3 2024 to get an in-depth view of Keros Therapeutics, Inc. (KROS)' financial performance, including balance sheets, income statements, and cash flow statements.
  2. SEC Filings – View Keros Therapeutics, Inc. (KROS)' latest filings with the U.S. Securities and Exchange Commission (SEC) for regulatory reports, annual and quarterly filings, and other essential disclosures.