Panbela Therapeutics, Inc. (PBLA) Bundle
A Brief History of Panbela Therapeutics, Inc. (PBLA)
Foundation and Early Years
Panbela Therapeutics, Inc. was founded in 2011 as a biotechnology company focused on developing innovative therapies for cancer treatment. The company is headquartered in Minneapolis, Minnesota.
Initial Public Offering
In the year 2014, Panbela Therapeutics went public, raising approximately $5 million through its initial public offering (IPO). The IPO was conducted at a price of $1.00 per share.
Key Developments in Drug Pipeline
Panbela's primary focus has been on the development of its lead product candidate, SBP-101, which is designed for the treatment of pancreatic cancer. In 2018, the company initiated a Phase 1 clinical trial evaluating SBP-101 in patients with advanced solid tumors.
Financial Performance and Funding Rounds
As of Q1 2023, Panbela reported a cash position of approximately $10 million, which was expected to fund operations into Q3 2024. The company completed several financing rounds to support its clinical trials and operational costs.
| Year | Funding Amount (in $ millions) | Clinical Trial Phase | Lead Product Candidate |
|---|---|---|---|
| 2014 | 5 | N/A | N/A |
| 2018 | 10 | Phase 1 | SBP-101 |
| 2020 | 7 | Phase 2 | SBP-101 |
| 2021 | 8 | Phase 2 | SBP-101 |
| 2023 | 8 | Phase 2 | SBP-101 |
Collaboration and Partnerships
In 2022, Panbela announced collaborations with various academic institutions to enhance its research capabilities and expand its clinical trial efforts. These collaborations have provided access to cutting-edge technologies and expertise in oncology.
Market Performance
As of October 2023, Panbela’s stock price is approximately $0.50, with a market capitalization of around $20 million. The stock has experienced significant volatility, reflective of the biotechnology sector's challenges and successes.
Regulatory Milestones
Panbela submitted several Investigational New Drug (IND) applications to the FDA for SBP-101, with the most recent submission made in early 2023. The company awaits responses to advance its clinical trials.
Operational Challenges
The company has faced operational challenges, including delays in clinical trials due to COVID-19. As of 2023, the company is focused on overcoming these issues to accelerate the development of its therapeutic candidates.
Future Outlook
The company is positioned to advance its clinical programs and explore additional indications for SBP-101, with potential expansions into combination therapies being evaluated. Financial sustainability and securing additional funding remain priorities for future growth.
A Who Owns Panbela Therapeutics, Inc. (PBLA)
Ownership Structure
Ownership Structure
Panbela Therapeutics, Inc. (PBLA) operates within a corporate structure that includes a variety of institutional and retail investors. As of the latest data in October 2023, the ownership distribution is as follows:
| Owner Type | Percentage Ownership | Number of Shares |
|---|---|---|
| Institutions | 20% | 2,000,000 |
| Individual Investors | 35% | 3,500,000 |
| Company Executives and Directors | 10% | 1,000,000 |
| Other Insiders | 5% | 500,000 |
| Public Float | 30% | 3,000,000 |
Major Institutional Shareholders
Several institutional shareholders hold significant stakes in Panbela Therapeutics. The following is a summary of the major institutional investors as of the latest available reports:
| Institution | Shares Owned | Percentage of Total Shares |
|---|---|---|
| Vanguard Group | 1,000,000 | 10% |
| BlackRock, Inc. | 800,000 | 8% |
| State Street Corporation | 600,000 | 6% |
| Fidelity Investments | 400,000 | 4% |
| Other Institutions | 200,000 | 2% |
Executive Ownership
The executive team at Panbela Therapeutics also holds a notable percentage of shares. The following table details the ownership by key executives:
| Executive | Title | Shares Owned | Percentage of Total Shares |
|---|---|---|---|
| David G. J. Miller | CEO | 500,000 | 5% |
| Catherine M. Johnson | COO | 300,000 | 3% |
| J. Mark McClain | CFO | 200,000 | 2% |
| Anne B. Roberts | CSO | 100,000 | 1% |
Recent Stock Performance
As of October 2023, Panbela Therapeutics, Inc. trades on the NASDAQ under the symbol PBLA. The following are key stock performance metrics:
| Metric | Value |
|---|---|
| Current Share Price | $0.50 |
| Market Capitalization | $50 million |
| 52-Week High | $1.20 |
| 52-Week Low | $0.30 |
| Volume (Average Trading) | 150,000 shares |
Future Ownership Changes
Looking ahead, Panbela Therapeutics may experience changes in ownership due to potential strategic partnerships, future funding rounds, or mergers. Current trends suggest increased interest from venture capitalists and biotech investors.
Panbela Therapeutics, Inc. (PBLA) Mission Statement
Panbela Therapeutics, Inc. is dedicated to developing innovative therapies for cancer patients. The company focuses on unmet medical needs and aims to provide treatments that improve survival rates and enhance the quality of life for patients diagnosed with various types of cancer.
Core Values
- Patient-Centric Approach: Prioritizing patient needs in all aspects of development.
- Innovation: Committing to the advancement of cancer treatment through cutting-edge research.
- Integrity: Upholding the highest ethical standards in conducting clinical trials and business practices.
- Collaboration: Partnering with leading research institutions and healthcare professionals.
Strategic Goals
- Enhance Pipeline: Expanding research and development efforts to discover new cancer therapies.
- Clinical Trials: Advancing clinical trials for its lead product candidates to gather essential data.
- Market Expansion: Strategizing for market entry and penetration in various geographic regions.
- Partnership Development: Seeking collaborations with pharmaceutical companies for co-development.
Financial Overview
As of September 2023, Panbela Therapeutics reported the following financial data:
| Metric | Value |
|---|---|
| Market Capitalization | $20.5 million |
| Cash Position (Q2 2023) | $5.7 million |
| Revenue (2022) | $2.3 million |
| Net Loss (2022) | -$6.2 million |
| Research and Development Expenses (2022) | $3.9 million |
| General and Administrative Expenses (2022) | $2.3 million |
Research and Development Focus
Panbela Therapeutics is actively focusing on its key product candidates:
- SBP-101: A therapeutic candidate currently in Phase 2 clinical trials for pancreatic cancer.
- SBP-102: Investigating this compound for its potential in treating solid tumors.
- Partnerships: Collaborating with external research organizations to leverage expertise and resources.
Future Outlook
The company aims to secure additional funding to support ongoing clinical trials and operational needs. With an emphasis on innovation and collaboration, Panbela Therapeutics is positioned to make significant strides in the oncology space.
How Panbela Therapeutics, Inc. (PBLA) Works
Overview
Panbela Therapeutics, Inc. (PBLA) is a clinical-stage biopharmaceutical company focused on the development of novel therapies for the treatment of cancer. The company's primary product candidate is SBP-101, which is intended for the treatment of pancreatic cancer and other difficult-to-treat cancers.
Business Model
Panbela operates on a business model that emphasizes research and development (R&D) within the oncology sector. The company conducts clinical trials to evaluate the efficacy and safety of its drug candidates, seeking to bring innovative therapies to market.
Financial Performance
As of the latest reporting period, Panbela Therapeutics' financial metrics were as follows:
| Metric | Amount (in USD) |
|---|---|
| Market Capitalization | $22.38 million |
| Cash and Cash Equivalents | $11.2 million |
| Research and Development Expenses (2022) | $2.45 million |
| General and Administrative Expenses (2022) | $4.1 million |
| Net Loss for Q2 2023 | $1.5 million |
Clinical Trials
Phase I clinical trials for SBP-101 commenced in various locations, evaluating its safety and preliminary efficacy in patients with advanced pancreatic cancer.
- Trial Duration: Expected to last 18 months
- Participants: 100 patients targeted
- Primary Endpoint: Safety and tolerability
Product Pipeline
Panbela has additional compounds in its pipeline, focusing on differentiated therapies for various cancers.
| Product Candidate | Indication | Clinical Stage |
|---|---|---|
| SBP-101 | Pancreatic cancer | Phase I |
| SBP-201 | Other solid tumors | Preclinical |
Collaborations and Partnerships
Panbela pursues strategic collaborations with research institutions and other companies to enhance its R&D capabilities.
- Partnerships with academic institutions for clinical research
- Collaborations with contract research organizations (CROs) for trial management
Regulatory Strategy
The company is working closely with the FDA to ensure compliance with regulations and to facilitate the approval process for its drug candidates.
- Fast Track Designation: Applied for SBP-101
- Orphan Drug Designation: Aimed for pancreatic cancer therapy
Market Landscape
The global pancreatic cancer treatment market is projected to reach $4.7 billion by 2028, indicating the potential market opportunity for Panbela's products.
| Year | Market Size (in USD) |
|---|---|
| 2023 | $3.2 billion |
| 2024 | $3.6 billion |
| 2025 | $4.1 billion |
| 2026 | $4.5 billion |
| 2027 | $4.6 billion |
| 2028 | $4.7 billion |
Investment and Funding
As of late 2023, Panbela has engaged in multiple funding rounds to support its ongoing clinical studies and operational needs.
- Recent Funding Round: Completed in August 2023
- Amount Raised: $5 million
- Use of Proceeds: Primarily allocated to R&D initiatives
Conclusion
Panbela Therapeutics, Inc. continues to develop its pipeline with the aim of addressing significant unmet medical needs in oncology, leveraging strategic partnerships and maintaining a focus on regulatory compliance to navigate the complexities of the pharmaceutical landscape.
How Panbela Therapeutics, Inc. (PBLA) Makes Money
Overview of Business Model
Panbela Therapeutics, Inc. operates as a clinical-stage biopharmaceutical company focused on developing innovative treatments for cancer. Their primary product, SBP-101, is a novel therapy aimed at treating pancreatic and other cancers.
Revenue Generation Sources
- Product Sales
- Grants and Collaborations
- Licensing Agreements
- Equity Financing
Product Sales
As of the latest financial reports, Panbela has not yet generated revenue from product sales due to its status as a clinical-stage company. However, the market potential for their lead product could be significant upon approval.
Grants and Collaborations
Panbela Therapeutics has received various grants to support its research and development efforts. For instance, in 2022, they secured a grant of $1 million from the National Cancer Institute (NCI) to advance SBP-101.
Licensing Agreements
Licensing agreements can provide substantial income. In 2021, they entered a licensing deal with a pharmaceutical company, which included an upfront payment of $2 million and potential milestone payments totaling $20 million.
Equity Financing
Panbela has raised funds through equity financing. In April 2023, they announced a public offering that raised approximately $5 million to support ongoing clinical trials and operational activities.
Financial Performance Metrics
| Year | Revenue | R&D Expenses | Net Loss |
|---|---|---|---|
| 2020 | $0 | $3.2 million | $4.5 million |
| 2021 | $0 | $4.1 million | $5.4 million |
| 2022 | $0 | $5.2 million | $6.5 million |
| 2023 (Q1) | $0 | $1.5 million | $2.0 million |
Market Potential
The potential market for SBP-101 is substantial, especially given the high mortality rates associated with pancreatic cancer. Estimates suggest that the global pancreatic cancer drug market could exceed $3 billion by 2026.
Challenges and Risks
Despite the promising market, Panbela faces challenges, including regulatory hurdles associated with drug approval processes and competition from other therapies. The projected costs for clinical trials can also affect the financial outlook.
Future Financial Projections
Analysts predict that upon successful completion of clinical trials and subsequent FDA approval, Panbela could generate revenues exceeding $100 million annually within a few years post-launch.
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