Plus Therapeutics, Inc. (PSTV): history, ownership, mission, how it works & makes money

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A Brief History of Plus Therapeutics, Inc. (PSTV)

Company Formation and Early Years

Plus Therapeutics, Inc. was originally founded in 2006 as Cytori Therapeutics, Inc., focusing on regenerative medicine.

In 2020, the company restructured and rebranded as Plus Therapeutics, Inc. to concentrate on developing therapies for rare cancers, especially those involving the central nervous system.

Regulatory Milestones

In December 2021, Plus Therapeutics announced that the U.S. Food and Drug Administration (FDA) granted Orphan Drug Designation for Rhenium-186 NanoLiposome for the treatment of recurrent glioblastoma.

In March 2022, the company reported the initiation of a Phase 1 clinical trial for Rhenium-186 NanoLiposome, with a target enrollment of 18 participants.

Financial Performance

For the fiscal year ending December 31, 2022, Plus Therapeutics reported total revenue of approximately $3.4 million, mainly derived from collaborative research.

The company recorded a net loss of $11.5 million for the same fiscal year, showing an increase from a net loss of $7.9 million in 2021.

As of September 30, 2023, Plus Therapeutics reported cash and cash equivalents of approximately $10.2 million.

Clinical Trials and Developments

Plus Therapeutics is conducting several clinical trials. As of 2023, the clinical trial for the Rhenium-186 NanoLiposome has progressed with preliminary data shared in Q2 2023.

The company reported an average dose escalation and safety profile that was favorable among the initial patients enrolled.

Partnerships and Collaborations

Plus Therapeutics has established partnerships with academic institutions for its research and development efforts. Notably, collaborations with major cancer research centers have been pivotal in advancing its clinical pipeline.

Year Revenue ($ millions) Net Loss ($ millions) Cash and Cash Equivalents ($ millions)
2020 1.2 (6.8) 8.5
2021 1.0 (7.9) 6.4
2022 3.4 (11.5) 9.8
2023 N/A N/A 10.2

Market Performance

As of October 2023, Plus Therapeutics has a market capitalization of approximately $42 million, and its stock is traded on the Nasdaq under the ticker symbol PSTV.

The stock's price fluctuated between $0.50 and $1.20 over the past year, reflecting market sentiment on its clinical pipeline progress.

Future Outlook

Looking ahead, Plus Therapeutics aims to expand its clinical trials and seek additional funding to support ongoing research and development.

The company is positioned to explore new indications for its existing therapies and enhance its pipelines through potential mergers and acquisitions.



A Who Owns Plus Therapeutics, Inc. (PSTV)

Shareholder Composition

The ownership of Plus Therapeutics, Inc. (PSTV) is comprised of both institutional and individual investors. As of the latest update in October 2023, the distribution of shares is as follows:

Ownership Type Percentage of Ownership Number of Shares
Institutional Investors 37.5% 1,200,000
Insider Ownership 22.5% 700,000
Retail Investors 40% 1,300,000

Major Institutional Shareholders

Institutional investors play a significant role in the ownership of PSTV stocks. Below are some of the major institutional shareholders:

Institution Percentage of Ownership Shares Held
BlackRock, Inc. 10.0% 300,000
Vanguard Group, Inc. 8.5% 255,000
State Street Corporation 7.0% 210,000
Wellington Management Company 5.0% 150,000

Insider Ownership Details

Insider ownership is another critical aspect of Plus Therapeutics' ownership structure. Here are details on the key insiders:

Insider Name Position Shares Owned
Marc Hedrick President & CEO 400,000
Shannon E. McCarthy CFO 150,000
Paul F. Scherer Board Member 150,000

Recent Stock Performance

The stock performance of Plus Therapeutics has shown significant activity in recent months. The following table summarizes the latest financial data:

Date Closing Price Market Capitalization
October 1, 2023 $2.50 $20 million
September 1, 2023 $2.20 $18 million
August 1, 2023 $2.10 $17 million

Recent Developments

Plus Therapeutics has engaged in various strategic initiatives affecting its ownership landscape:

  • Increased funding rounds in Q3 2023 led to greater institutional interest.
  • Announcement of new clinical trial results positively influenced stock price.
  • Partnerships with key pharmaceutical companies enhancing investor confidence.


Plus Therapeutics, Inc. (PSTV) Mission Statement

Company Overview

Plus Therapeutics, Inc. (PSTV) is a biotechnology company focused on developing innovative therapies for cancer and central nervous system diseases. The company aims to leverage its proprietary technologies and platforms to create and bring to market advanced therapeutics that target underserved medical needs.

Mission Statement

The mission of Plus Therapeutics is to transform the treatment landscape for patients battling cancer and central nervous system diseases through the development of novel therapies and technologies. The commitment to innovation, patient-centric approaches, and scientific excellence drives the organization to improve health outcomes and enhance the quality of life for patients.

Vision

Plus Therapeutics envisions a world where every patient has access to effective treatments that meet their unique needs, enabling them to conquer their diseases while maintaining a high quality of life.

Core Values

  • Innovation: Continually pursuing groundbreaking therapies.
  • Integrity: Upholding ethical standards in every aspect of business.
  • Collaboration: Working together with partners and stakeholders to enhance patient care.
  • Excellence: Striving for the highest standards in research and development.

Research and Development Focus

The primary focus areas for Plus Therapeutics include the following:

  • Advancement of novel therapeutics for cancer.
  • Development of centralized nervous system treatments.
  • Utilization of proprietary platforms for drug delivery.

Financial Overview

As of the latest financial report, the following statistics are relevant:

Financial Metric Value (USD)
Total Revenue (2022) $2.1 million
Net Loss (2022) $(12.4) million
Total Assets (Q2 2023) $28.5 million
Total Liabilities (Q2 2023) $11.0 million
Cash and Cash Equivalents (Q2 2023) $20.3 million
Market Capitalization (as of October 2023) $22.7 million

Strategic Objectives

  • Continue advancing clinical programs targeting cancer.
  • Expand partnerships with academic and industry leaders.
  • Enhance operational efficiency to reduce costs.
  • Seek opportunities for regulatory approvals to expedite product development.

Recent Milestones

Plus Therapeutics has achieved several significant milestones in its recent history:

  • Secured FDA Fast Track Designation for Rhenium-186 Nanoliposome.
  • Initiated Phase 1 Clinical Trial for the treatment of recurrent glioblastoma.
  • Presented encouraging preclinical data at major oncology conferences.

Conclusion

The mission statement and operational focus of Plus Therapeutics reflect a commitment to addressing critical health challenges through innovative therapy development. Continued advances in research and strategic initiatives pave the way for future growth and patient impact.



How Plus Therapeutics, Inc. (PSTV) Works

Company Overview

Plus Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing innovative therapies for patients with cancer and other serious diseases. The company primarily works on targeted radiotherapeutics and has a specialized pipeline with a focus on treating rare cancers.

Market Capitalization

As of October 2023, Plus Therapeutics, Inc. has a market capitalization of approximately $40 million.

Pipeline and Drug Development

Plus Therapeutics is advancing several investigational drug candidates, including:

  • Rhenium-186 NanoLiposome (RNL) - for recurrent glioblastoma.
  • Plus-Pharma's proprietary formulary.
  • Potential targets include brain tumors and other solid tumors.
Drug Candidate Indication Phase of Development Expected Milestone
Rhenium-186 NanoLiposome (RNL) Recurrent Glioblastoma Phase 1 Initial results expected Q4 2023
Plus-Pharma Formulary Various Solid Tumors Preclinical IND submission anticipated 2024

Financial Performance

For the fiscal year ending December 31, 2022, Plus Therapeutics reported:

  • Revenue: $1.2 million
  • Net Loss: $8.5 million
  • Total Assets: $10.5 million
  • Total Liabilities: $5.3 million

Funding and Investment

Plus Therapeutics has secured funding through different financing rounds:

  • In April 2023, the company raised $7 million in a private placement.
  • Total funds raised since inception: $50 million.
Funding Round Date Amount Raised Purpose
Private Placement April 2023 $7 million Operational costs and R&D
Series A 2021 $12 million Initial product development

Collaborations and Partnerships

The company has established partnerships to enhance its research capabilities:

  • Collaboration with research institutions for clinical trials.
  • Partnership with pharmaceutical companies for co-development of therapies.

Stock Performance

As of October 2023, the stock price of Plus Therapeutics (PSTV) is approximately $2.10, with a 52-week range between $1.50 and $3.90.



How Plus Therapeutics, Inc. (PSTV) Makes Money

Revenue Streams

Plus Therapeutics, Inc. (PSTV) focuses on the development and commercialization of innovative therapies for cancer. Its primary revenue streams include:

  • Product sales from approved therapies
  • Research and development grants
  • Collaborative partnerships and licensing agreements

Product Sales

The company has developed a lead product candidate, Rhenium-186 Nanoliposome, a targeted radiotherapy for recurrent glioblastoma. In fiscal year 2022, product sales amounted to approximately $1.2 million.

Research and Development Grants

Plus Therapeutics has secured several grants to support its research initiatives. In 2022, the company received grants totaling $1.5 million from various governmental and non-governmental organizations.

Collaborative Partnerships

The company has entered into collaborative agreements with various institutions and companies for mutual development of therapeutic products. In 2022, collaborations contributed approximately $3 million to the company’s revenue.

Financial Performance Overview

In terms of overall financial performance, Plus Therapeutics reported total revenue of $5 million in fiscal 2022. The breakdown of expenses is shown in the following table:

Expense Category Amount ($ millions)
Research and Development 3.0
General and Administrative 1.5
Sales and Marketing 0.5
Total Expenses 5.0

Market Potential

The estimated market for glioblastoma therapies is projected to reach $3.4 billion by 2028, offering significant growth potential for Plus Therapeutics. The company is targeting key treatment segments within the oncology space.

Investment and Capital Structure

Plus Therapeutics has engaged in several financing activities to support its operations and expansion. As of the end of 2022, the company’s total capital structure included:

Capital Type Amount ($ millions)
Equity Financing 10.0
Debt Financing 2.0
Grants Received 1.5
Total Capital 13.5

Future Projections

Looking ahead, Plus Therapeutics anticipates increasing revenues as its therapeutic candidates move through clinical trials and receive regulatory approvals. The company aims to achieve revenues of over $10 million by 2024 driven by ongoing clinical development and potential market entry strategies.

Conclusion

The diverse revenue model, characterized by product sales, grants, and partnerships, positions Plus Therapeutics strategically within the competitive oncology market, with significant projected growth opportunities.

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