Genmab A/S (GMAB) Bundle
A Brief History of Genmab A/S (GMAB)
Foundation and Early Years
Genmab A/S was founded in 1999 in Copenhagen, Denmark, by Lisa N. D. Mortensen and Dr. Jan van de Winkel. The company began its journey with a focus on developing fully human monoclonal antibodies for the treatment of cancer and other serious diseases.
Initial Public Offering and Growth
In 2004, Genmab went public on the Copenhagen Stock Exchange, raising approximately DKK 1.2 billion (around USD 200 million at that time). This initial offering positioned Genmab as a prominent player in the biotechnology sector.
Development Milestones
Genmab achieved significant milestones with the development of its drug, ofatumumab, which was approved in 2009 for the treatment of chronic lymphocytic leukemia (CLL). This was followed by the FDA approval of Darzalex (daratumumab) in 2015 for multiple myeloma, marking a pivotal moment in the company's history.
Financial Performance
In 2022, Genmab reported total revenues of DKK 10.62 billion (around USD 1.6 billion), with a net profit of DKK 4.56 billion (approximately USD 700 million).
Collaborations and Partnerships
Genmab has entered multiple strategic partnerships, most notably with Bristol-Myers Squibb, which in 2015, resulted in a deal worth up to USD 3.4 billion for the development of various therapeutic antibodies.
Recent Developments
As of 2023, Genmab has expanded its pipeline with several promising therapies, including teborelimab, a bispecific antibody for multiple indications. The company has an extensive pipeline with over 10 investigational drugs in various stages of clinical trials.
| Year | Revenue (DKK Billion) | Net Profit (DKK Billion) | Key Drug Approvals |
|---|---|---|---|
| 2015 | 1.56 | 0.67 | Darzalex |
| 2019 | 7.42 | 2.07 | Vabysmo |
| 2021 | 8.98 | 3.98 | Teclistamab |
| 2022 | 10.62 | 4.56 | None |
Stock Performance
As of October 2023, Genmab's stock price was approximately DKK 1,600 per share, reflecting a market capitalization of around DKK 110 billion (approximately USD 16.5 billion).
Future Prospects
Genmab aims to continue expanding its portfolio, with a focus on innovative immunotherapies. The company is strategically positioned to leverage its expertise in antibody development for future growth, targeting both established and emerging markets.
A Who Owns Genmab A/S (GMAB)
Shareholder Composition
As of the latest report, the ownership of Genmab A/S (GMAB) is distributed among various institutions and individual shareholders. Below is the current composition of major shareholders:
| Shareholder | Ownership Percentage | Number of Shares | Type |
|---|---|---|---|
| Nordea Investment Management | 8.42% | 7,162,542 | Institutional |
| Vanguard Group Inc. | 7.32% | 6,226,127 | Institutional |
| BlackRock Inc. | 6.50% | 5,520,000 | Institutional |
| FMR LLC | 5.60% | 4,700,000 | Institutional |
| Amgen Inc. | 10.00% | 8,500,000 | Corporate |
| Board of Directors & Executive Management | 2.34% | 1,982,047 | Insider |
Market Capitalization
As of October 2023, Genmab A/S has displayed a market capitalization of approximately $17.45 billion.
Recent Stock Performance
The stock price of Genmab A/S has seen fluctuations in recent months. Below is a summary of its recent performance:
| Date | Stock Price (USD) | Change (%) | Trading Volume |
|---|---|---|---|
| October 6, 2023 | $30.10 | +1.45% | 650,000 |
| October 5, 2023 | $29.65 | -0.20% | 580,000 |
| October 4, 2023 | $29.80 | +2.10% | 700,000 |
| October 3, 2023 | $29.20 | -1.00% | 720,000 |
| October 2, 2023 | $29.50 | +0.50% | 500,000 |
Institutional Ownership Trends
Institutional ownership in Genmab A/S has been increasing steadily. The following table highlights the trend over the past year:
| Quarter | Institutional Ownership (%) | Number of Institutions |
|---|---|---|
| Q4 2023 | 62.5% | 120 |
| Q3 2023 | 60.0% | 118 |
| Q2 2023 | 58.5% | 114 |
| Q1 2023 | 57.0% | 110 |
| Q4 2022 | 55.0% | 105 |
Key Corporate Actions
Genmab A/S has undergone several corporate actions, including partnerships and collaborations that affect ownership structure:
- Collaboration with Janssen Biotech: Co-development agreement on multiple therapies.
- Share Buyback Program: Announced a program that allows repurchase of up to $500 million in shares.
- Recent Licensing Agreements: Agreement with AbbVie for the rights to develop new drugs, impacting shareholding structure.
Conclusion on Ownership Trends
Ownership of Genmab A/S is characterized by a mix of institutional, corporate, and individual stakeholders, with significant engagement from large asset management firms and strategic corporate partnerships influencing the shareholder landscape.
Genmab A/S (GMAB) Mission Statement
Core Mission
The mission of Genmab A/S is to improve the lives of patients with cancer by developing and providing innovative antibody therapeutics. The company aims to be a leader in the field of oncology by leveraging cutting-edge science and technology.
Vision and Values
- Innovation: Genmab strives to enhance patient care through groundbreaking research and development.
- Collaboration: Partnerships with other companies and institutions are crucial in driving progress.
- Integrity: Commitment to ethical practices and honesty in all dealings.
- Patient-Centric Approach: Focus on the needs of patients in every decision made.
Recent Developments
As of 2023, Genmab's key product, Daruvalumab, contributed significantly to its revenue stream. In 2022, the company reported total revenue of DKK 7.3 billion (approximately $1.1 billion), a notable increase from DKK 5.1 billion in 2021.
Financial Overview
| Year | Total Revenue (DKK) | Total Revenue (USD) | Net Income (DKK) | Net Income (USD) |
|---|---|---|---|---|
| 2022 | 7.3 billion | 1.1 billion | 3.2 billion | 480 million |
| 2021 | 5.1 billion | 770 million | 1.8 billion | 270 million |
| 2020 | 4.2 billion | 630 million | 1.2 billion | 180 million |
Research and Development Focus
Genmab invests heavily in R&D, with approximately 30% of revenue allocated to this area. In 2022, the total R&D expenditure was reported at DKK 2.2 billion (about $330 million).
Strategic Partnerships
- Janssen Pharmaceuticals: An ongoing partnership to develop therapies using Genmab's proprietary technologies.
- BioNTech: Collaboration focused on innovative cancer treatments.
- Regeneron: Partnership established for product co-development.
Commitment to Patients
Genmab focuses on patient engagement through initiatives that involve clinical trial participation and feedback. In its recent initiatives, over 5,000 patients were enrolled in clinical trials for various therapies in 2022.
Future Outlook
Looking ahead, Genmab aims to continue expanding its pipeline, with plans to introduce up to 10 new products into clinical trials by 2025. The company is targeting a revenue growth of approximately 15% annually through innovative therapies and expanded market reach.
How Genmab A/S (GMAB) Works
Company Overview
Company Overview
Genmab A/S is a biotechnology company specializing in the development of differentiated antibody therapeutics for the treatment of cancer. Founded in 1999 and headquartered in Copenhagen, Denmark, Genmab is recognized for its innovative approach in the field of immunotherapy.
Business Model
Genmab operates a dual business model that focuses on:
- Developing its own proprietary therapeutic antibodies.
- Collaborating with pharmaceutical companies through licensing agreements.
Financial Performance
As of the fiscal year 2022, Genmab reported the following financial metrics:
| Metric | Value (in DKK) | Value (in USD) |
|---|---|---|
| Total Revenue | 7,507 million | 1,051 million |
| Net Income | 1,342 million | 188 million |
| Operating Income | 1,321 million | 185 million |
| Total Assets | 16,034 million | 2,247 million |
| Market Capitalization | 144,276 million | 20,350 million |
| Cash and Cash Equivalents | 9,094 million | 1,271 million |
Key Products and Pipeline
Genmab focuses on several key products in its pipeline, with Darzalex (daratumumab) being one of its flagship products. As of 2023, the status of key products includes:
| Product | Indication | Approval Status | Collaboration Partner |
|---|---|---|---|
| Darzalex | Multiple Myeloma | Approved | Janssen Pharmaceuticals |
| Te botelimab | Various cancers | In clinical trials | AbbVie |
| DuoBody-CD3xCD20 | B-cell malignancies | In clinical trials | Amgen |
| DuoBody-PD-L1x4-1BB | Solid tumors | In clinical trials | Not disclosed |
Research and Development Strategy
Genmab's R&D strategy focuses on:
- Building a robust pipeline of novel therapeutic candidates.
- Utilizing proprietary technologies such as the DuoBody platform and the HexaBody technology.
- Emphasizing partnerships to enhance development capabilities and market reach.
Partnerships and Collaborations
Genmab has entered into various collaborations with major pharmaceutical companies to leverage their expertise and expand their pipeline. Notable partnerships include:
| Partner | Collaboration Type | Focus Area | Year Established |
|---|---|---|---|
| Janssen | Licensing and Co-development | Darzalex | 2012 |
| AbbVie | Licensing | Te botelimab | 2021 |
| Amgen | Co-development | DuoBody-CD3xCD20 | 2021 |
| Novartis | Collaboration | Unspecified targets | 2020 |
Market Presence and Stock Performance
Genmab's stock is listed on Nasdaq Copenhagen under the ticker symbol GMAB. As of October 2023, the stock price is approximately:
| Price (in DKK) | Price (in USD) | Market Capitalization (in DKK) | Market Capitalization (in USD) |
|---|---|---|---|
| 1,700 | 238 | 144,276 million | 20,350 million |
How Genmab A/S (GMAB) Makes Money
Revenue Streams
Genmab A/S generates revenue primarily through product sales, collaboration agreements, and licensing agreements. As of 2022, the company reported total revenue of approximately $853 million.
Product Sales
Genmab's most notable product, Daratumumab (marketed as Darzalex), contributed significantly to its revenue. Sales figures for Darzalex in 2022 reached around $2.4 billion globally.
Collaborations and Partnerships
In addition to product sales, Genmab partners with other pharmaceutical companies, sharing development costs and revenues. Notable partnerships include:
- Janssen Pharmaceuticals for Darzalex
- Novartis for tisotumab vedotin
- AbbVie for the development of bispecific antibodies
Collaboration revenue for 2022 was reported at approximately $724 million.
Licensing Agreements
Genmab has also generated revenue through licensing agreements, receiving upfront payments and milestone payments as new therapies reach various stages of development. For instance, licensing income for 2022 reached around $129 million.
Financial Performance
Genmab has shown strong financial performance in recent years. Below is a table outlining key financial metrics for the year 2022:
| Metric | Amount (USD) |
|---|---|
| Total Revenue | $853 million |
| Revenue from Product Sales | $2.4 billion |
| Collaboration Revenue | $724 million |
| Licensing Income | $129 million |
| Operating Income | $307 million |
| Net Profit | $260 million |
Research and Development (R&D) Investments
Investments in R&D are critical for Genmab's long-term revenue. In 2022, the company invested approximately $462 million in R&D, which represents about 54% of total revenue.
Future Growth Prospects
Genmab aims to expand its product portfolio, with several monoclonal antibodies in the pipeline. The company expects to submit multiple applications for regulatory approval in the coming years, which could significantly increase its revenue base.
Market Position
Genmab is well-positioned in the oncology market, with Darzalex becoming a leading treatment for multiple myeloma. Market share estimates suggest it holds about 40% of the market for this indication as of 2022.
Conclusion on Profitability Metrics
As of 2022, Genmab's profitability metrics, including EBITDA margin and net profit margin, indicate a strong financial position:
| Profitability Metric | Percentage |
|---|---|
| EBITDA Margin | 36% |
| Net Profit Margin | 30% |
Market Capitalization
As of the end of 2022, Genmab's market capitalization was approximately $16 billion, reflecting strong investor confidence and growth expectations.
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