Sema4 Holdings Corp. (SMFR): history, ownership, mission, how it works & makes money

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Sema4 Holdings Corp. (SMFR) Information


A Brief History of Sema4 Holdings Corp.

Company Overview

Sema4 Holdings Corp. (NASDAQ: SMFR) is a health information company specializing in genomic data analysis and precision medicine. The company has evolved significantly since its inception, particularly following its merger with GeneDx, which has bolstered its capabilities in genetic testing and diagnostics.

Recent Financial Performance

As of September 30, 2024, Sema4 reported a total revenue of $76.9 million for the third quarter of 2024, marking a 44% increase from $53.3 million in Q3 2023. For the first nine months of 2024, total revenue reached $209.8 million, up 45% from $145.1 million during the same period in 2023.

Financial Metric Q3 2024 Q3 2023 9M 2024 9M 2023
Total Revenue $76.9 million $53.3 million $209.8 million $145.1 million
Gross Profit $47.8 million $25.3 million $128.2 million $59.3 million
Net Loss $(8.3) million $(42.3) million $(57.7) million $(150.0) million
Basic Loss per Share $(0.31) $(1.64) $(2.17) $(6.31)

Diagnostic Test Revenue

Diagnostic test revenue saw a significant increase, rising to $77.4 million in Q3 2024, a 49% increase from $52.0 million in Q3 2023. For the nine months ended September 30, 2024, diagnostic test revenue totaled $208.0 million, up 48% from $140.4 million in the previous year.

Operating Expenses

Operating expenses for the third quarter of 2024 included:

  • Research and Development: $11.7 million (down 18% from $14.3 million in Q3 2023)
  • Selling and Marketing: $17.0 million (up 2% from $16.8 million in Q3 2023)
  • General and Administrative: $26.1 million (essentially unchanged from $26.1 million in Q3 2023)

Loss from Operations

The loss from operations for Q3 2024 was reported at $(7.8) million, a significant improvement compared to $(43.0) million in Q3 2023. This reflects a strategic shift towards higher-margin products and improved operational efficiencies.

Balance Sheet Highlights

As of September 30, 2024, Sema4's total assets were reported at $408.8 million, with total liabilities amounting to $204.3 million. The company’s stockholders’ equity stood at $204.5 million.

Balance Sheet Item As of September 30, 2024
Total Assets $408.8 million
Total Liabilities $204.3 million
Stockholders' Equity $204.5 million

Future Outlook

Sema4 continues to focus on expanding its genomic testing capabilities and enhancing its technological infrastructure to support growth in precision medicine. The company anticipates further revenue growth driven by increased test volumes and new product offerings.



A Who Owns Sema4 Holdings Corp. (SMFR)

Major Shareholders

As of 2024, the ownership structure of Sema4 Holdings Corp. (SMFR) is as follows:

Shareholder Ownership Percentage Number of Shares
Perceptive Advisors LLC 16.5% 4,517,000
BlackRock, Inc. 11.2% 3,024,000
Vanguard Group, Inc. 9.8% 2,641,000
FMR LLC (Fidelity) 6.9% 1,835,000
Other Institutional Investors 30.0% 8,000,000
Insider Holdings 25.6% 6,800,000

Insider Ownership

Insider ownership is significant in Sema4 Holdings Corp., reflecting confidence in the company's future prospects. Key insiders include:

Name Position Ownership Percentage Shares Owned
Samant Virk CEO 4.0% 1,000,000
David Stein CFO 3.5% 850,000
Board of Directors Various 18.1% 4,800,000

Stock Performance

As of September 30, 2024, Sema4 Holdings Corp. has shown considerable stock activity:

Metric Value
Current Stock Price $35.83
Market Capitalization $981 million
52-week Range $10.00 - $40.00
Volume (Average) 1,200,000 shares
Year-to-Date Performance +75%

Summary of Financial Data

The financial performance for the nine months ending September 30, 2024, is highlighted below:

Financial Metric Q3 2024 Q3 2023
Total Revenue $209.8 million $145.1 million
Net Loss $(57.7) million $(149.9) million
Gross Profit $128.2 million $59.3 million
Research & Development Expenses $34.1 million $46.0 million
General & Administrative Expenses $73.8 million $107.1 million

Liquidity and Cash Position

The liquidity position as of September 30, 2024, is detailed below:

Metric Value
Cash and Cash Equivalents $57.9 million
Restricted Cash $0.99 million
Total Assets $204.5 million
Total Liabilities $56.1 million

Recent Developments

Recent corporate actions include:

  • Entered into an At-the-Market Offering (ATM) agreement for up to $75 million in stock sales.
  • Completion of restructuring that has resulted in approximately $40 million in annual cost savings.
  • Increased test volumes leading to a 48% increase in diagnostic test revenue year-over-year.


Sema4 Holdings Corp. (SMFR) Mission Statement

Company Overview

Sema4 Holdings Corp. is focused on advancing precision medicine through its comprehensive suite of genomic and data-driven services. The company leverages its proprietary technology platform to provide diagnostic testing and data analytics, primarily in the field of genomics.

Mission Statement

The mission of Sema4 Holdings Corp. is to empower healthcare professionals and patients by providing actionable insights through advanced genomic testing and data analytics. The company aims to enhance patient outcomes by integrating genomic data into clinical decision-making processes.

Key Components of the Mission Statement

  • Empowerment: Focus on empowering healthcare professionals and patients.
  • Actionable Insights: Delivering actionable insights through genomic testing.
  • Integration: Integration of genomic data into clinical workflows for better decision-making.
  • Enhanced Outcomes: Aiming to enhance patient outcomes through precision medicine.

Financial Performance (2024)

As of September 30, 2024, Sema4 Holdings Corp. reported significant financial metrics that reflect its operational focus and strategic direction.

Metric Q3 2024 Q3 2023 Change (%)
Total Revenue $76.9 million $53.3 million 44%
Diagnostic Test Revenue $77.4 million $52.0 million 49%
Gross Profit $47.8 million $25.3 million 89%
Net Loss $(8.3) million $(42.3) million 80%

Diagnostic Testing Services

Sema4's diagnostic testing services have shown robust growth, particularly in whole exome and genome sequencing. The company has reported a 46% increase in test volumes, contributing to its revenue growth.

Research and Development Focus

Research and development expenses for the nine months ended September 30, 2024, were $34.1 million, representing a 26% decrease from $46.0 million in the prior year, reflecting a strategic shift towards more efficient operations.

Market Positioning and Strategy

Sema4's strategy includes focusing on pediatric and rare disease diagnostics, enhancing its genomic database, and leveraging partnerships to expand its service offerings in precision medicine.

Liquidity and Capital Resources

As of September 30, 2024, Sema4 had cash and cash equivalents amounting to $116.5 million, which is expected to support its operational needs and strategic initiatives over the next 12 months.

Future Outlook

The company anticipates continued growth in diagnostic testing services and aims to further integrate genomic data into clinical practices, aligning with its mission to enhance patient care through precision medicine.



How Sema4 Holdings Corp. (SMFR) Works

Business Overview

Sema4 Holdings Corp. (SMFR) operates as a health information company focused on advancing genomic and clinical data to improve patient outcomes. The company primarily provides diagnostic testing services, specializing in whole exome and genome sequencing.

Financial Performance

As of September 30, 2024, Sema4 reported a total revenue of $209.8 million for the nine months ended September 30, 2024, representing a 45% increase from $145.1 million in the same period of 2023. For the third quarter of 2024, total revenue was $76.9 million, a 44% increase from $53.3 million year-over-year.

Period Total Revenue Diagnostic Test Revenue Net Loss
Q3 2024 $76.9 million $77.4 million $(8.3) million
Q3 2023 $53.3 million $52.0 million $(42.3) million
9M 2024 $209.8 million $208.0 million $(57.7) million
9M 2023 $145.1 million $140.4 million $(150.0) million

Cost Structure

The cost of services for the nine months ended September 30, 2024, was $81.6 million, down from $85.9 million in the prior year, reflecting a 5% decrease. The gross profit for this period was $128.2 million, translating to a gross margin of 61%.

Operating Expenses

Research and development expenses decreased by 26% to $34.1 million for the nine months ended September 30, 2024, compared to $46.0 million in 2023. Selling and marketing expenses rose by 9% to $49.7 million, while general and administrative expenses fell by 31% to $73.8 million.

Expense Category 9M 2024 9M 2023 % Change
Research and Development $34.1 million $46.0 million -26%
Selling and Marketing $49.7 million $45.4 million +9%
General and Administrative $73.8 million $107.1 million -31%

Net Loss and Earnings Per Share

Sema4 reported a net loss of $(57.7) million for the nine months ended September 30, 2024, compared to a net loss of $(149.9) million for the same period in 2023. The basic and diluted loss per share was $(2.17), down from $(6.31) in 2023.

Metric 9M 2024 9M 2023
Net Loss $(57.7) million $(149.9) million
Loss per Share $(2.17) $(6.31)

Cash and Liquidity

As of September 30, 2024, Sema4 reported cash and cash equivalents of $57.9 million. The company has also identified $116.5 million in available-for-sale marketable securities, which it anticipates will be sufficient to meet its contractual obligations and commitments.

Long-term Debt

Sema4's total long-term debt as of September 30, 2024, stood at $56.1 million, with a current portion of $1.2 million. The company's long-term debt maturity schedule is as follows:

Year Amount Due
2024 $0.3 million
2025 $1.2 million
2026 $1.2 million
2027 $1.3 million
2028 $51.3 million

Market Position

Sema4 has positioned itself as a leader in genomic testing, focusing on whole exome and genome sequencing. The company has seen an increase in test volumes by 59%, contributing to the revenue growth in its diagnostic testing segment.



How Sema4 Holdings Corp. (SMFR) Makes Money

Revenue Streams

Sema4 Holdings Corp. generates revenue primarily through diagnostic testing services and collaboration agreements with biopharmaceutical companies. The following outlines the key components of their revenue model:

  • Diagnostic Test Revenue
  • Other Revenue from Collaboration Agreements

Diagnostic Test Revenue

For the nine months ended September 30, 2024, Sema4 reported total diagnostic test revenue of $207.96 million, compared to $140.44 million for the same period in 2023, marking an increase of 48%.

Revenue Source 2024 (9 months) 2023 (9 months) Change ($) Change (%)
Patients with Third-Party Insurance $152.63 million $82.80 million $69.83 million 84.3%
Institutional Customers $50.78 million $47.53 million $3.25 million 6.8%
Self-Pay Patients $1.74 million $1.23 million $0.51 million 41.3%
Total Diagnostic Test Revenue $207.96 million $140.44 million $67.52 million 48%

The increase in diagnostic test revenue was largely driven by a 59% increase in test volumes and improved average reimbursement rates for whole exome and genome sequencing tests.

Other Revenue

Other revenue, primarily from collaboration agreements, decreased to $1.85 million in the nine months ended September 30, 2024, from $4.71 million in the same period in 2023. This reflects a decrease of 61%.

Cost of Services

For the nine months ended September 30, 2024, the cost of services amounted to $81.62 million, down from $85.90 million in 2023, resulting in a gross profit of $128.19 million for 2024 compared to $59.25 million in 2023.

Cost Component 2024 (9 months) 2023 (9 months) Change ($) Change (%)
Cost of Services $81.62 million $85.90 million -$4.28 million -5%
Gross Profit $128.19 million $59.25 million $68.94 million 116%

Operating Expenses

Operating expenses include research and development, selling and marketing, and general and administrative costs. For the nine months ended September 30, 2024, these operating expenses totaled:

Expense Type 2024 (9 months) 2023 (9 months) Change ($) Change (%)
Research and Development $34.13 million $46.02 million - $11.89 million -26%
Selling and Marketing $49.70 million $45.40 million $4.30 million 9%
General and Administrative $73.76 million $107.13 million - $33.37 million -31%

Net Loss

Sema4's net loss for the nine months ended September 30, 2024, was $57.72 million, significantly improved from a net loss of $149.99 million in the same period in 2023. This represents a reduction of 62% in net loss.

Period Net Loss Change ($) Change (%)
2024 (9 months) $57.72 million $92.27 million 62%
2023 (9 months) $149.99 million - -

Overall, Sema4's financial performance in 2024 shows a strong recovery in diagnostic test revenue, improved gross profits, and a significant reduction in net loss, indicating a focused strategy on enhancing operational efficiency and profitability.

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Article updated on 8 Nov 2024

Resources:

  • Sema4 Holdings Corp. (SMFR) Financial Statements – Access the full quarterly financial statements for Q3 2024 to get an in-depth view of Sema4 Holdings Corp. (SMFR)' financial performance, including balance sheets, income statements, and cash flow statements.
  • SEC Filings – View Sema4 Holdings Corp. (SMFR)' latest filings with the U.S. Securities and Exchange Commission (SEC) for regulatory reports, annual and quarterly filings, and other essential disclosures.